Le N, Yousefi S, Vaziri N, Carandang G, Ocariz J, Cesario T
Department of Medicine and Academic Geriatric Resource Center, University of California, Irvine.
J Biol Regul Homeost Agents. 1988 Oct-Dec;2(4):199-204.
Sex hormones including estrogens, progesterone and testosterones are known to have adverse effects on the immune system and particularly on the proliferative response. Since cytokine production is known to be dissociable from the proliferation of lymphocytes and since other steroid hormones profoundly affect cytokine production, we felt it would be important to know the effect of sex steroids on the production of interferons (IFN), particularly since the latter are known to be key substances in the immune response. We have shown estradiol can slightly reduce gamma IFN yields with certain inducers (Con A, SEA) but only in pharmacologic concentrations. Similarly, progesterone had a modest effect in the same concentrations but only when Con A was the inducer. Testosterone did not effect IFN titers at any concentration. None of the sex steroids affected alpha IFN production and none of them influenced the bioactivity of either IFN species. In all cases these hormones diminished proliferative responses as has been previously noted.
已知包括雌激素、孕激素和睾酮在内的性激素会对免疫系统产生不利影响，尤其是对增殖反应。由于已知细胞因子的产生与淋巴细胞的增殖是可分离的，并且由于其他类固醇激素会深刻影响细胞因子的产生，我们认为了解性类固醇对干扰素（IFN）产生的影响很重要，特别是因为后者是免疫反应中的关键物质。我们已经表明，雌二醇在某些诱导剂（刀豆蛋白A、SEA）作用下能轻微降低γ干扰素产量，但仅在药理浓度下。同样，孕激素在相同浓度下有适度影响，但仅当刀豆蛋白A为诱导剂时。睾酮在任何浓度下都不影响干扰素滴度。没有一种性类固醇影响α干扰素的产生，也没有一种影响任一干扰素种类的生物活性。在所有情况下，这些激素都会如先前所述降低增殖反应。
