Dudley T H, Moinuddin S
Department of Pathology, Baptist Memorial Hospital, Memphis, Tennessee 38146.
Am J Clin Pathol. 1989 Jun;91(6):714-7. doi: 10.1093/ajcp/91.6.714.
Neuroendocrine (Merkel cell) carcinoma of the skin is a rare entity. Often locally aggressive, this lesion may also metastasize to organ systems, including bone, liver, and brain. The authors report a case of a 64-year-old male who presented with hoarseness and dysphagia 17 months after resection of a primary Merkel cell carcinoma of the nose. Additional studies revealed bilateral vocal cord paralysis secondary to central nervous system dysfunction. Cytologic evaluation of the cerebrospinal fluid revealed malignant tumor cells consistent with metastatic Merkel cell carcinoma. Presented are the cytologic and immunohistochemical findings in a case of metastatic Merkel cell carcinoma involving the central nervous system.
皮肤神经内分泌（默克尔细胞）癌是一种罕见的疾病。这种病变通常具有局部侵袭性，也可能转移至包括骨骼、肝脏和脑在内的多个器官系统。作者报告了一例64岁男性患者，该患者在鼻部原发性默克尔细胞癌切除术后17个月出现声音嘶哑和吞咽困难。进一步检查发现双侧声带麻痹是由中枢神经系统功能障碍所致。脑脊液的细胞学评估显示恶性肿瘤细胞，与转移性默克尔细胞癌相符。本文展示了一例累及中枢神经系统的转移性默克尔细胞癌的细胞学和免疫组化结果。
