Longo F, Califano L, Mangone G M, Errico M E
Department of Maxillofacial Surgery, School of Medicine and Surgery, University of Naples Federico II, Italy.
J Oral Pathol Med. 1999 Feb;28(2):88-91. doi: 10.1111/j.1600-0714.1999.tb02002.x.
Merkel cell carcinoma (Mcc) is an uncommon and aggressive tumour with neuroendocrine features that occur predominantly in the head and neck region. The rarity of this tumour, especially when it arises in the oral mucosa, makes both early identification and standardisation of treatment difficult, particularly as regards complementary treatment. The availability of monoclonal antibodies with restricted specificity for some antigens thought to be related to neuroendocrine carcinomas, such as Merkel cell carcinoma, and ultrastructural studies offer some new leads to investigation. This has allowed, a greater number of these tumours to be discovered, thereby increasing the chances of effective management. A case of Mcc of the floor of the mouth is reported, together with the results of cytokeratin, neuron specific enolase and chromogranin immunohistochemistry.
默克尔细胞癌（Mcc）是一种罕见且侵袭性强的具有神经内分泌特征的肿瘤，主要发生在头颈部区域。这种肿瘤的罕见性，尤其是当其发生于口腔黏膜时，使得早期识别和治疗标准化变得困难，特别是在辅助治疗方面。针对一些被认为与神经内分泌癌（如默克尔细胞癌）相关的抗原具有受限特异性的单克隆抗体的可用性以及超微结构研究提供了一些新的研究线索。这使得能够发现更多此类肿瘤，从而增加有效管理的机会。本文报告了一例口底默克尔细胞癌病例以及细胞角蛋白、神经元特异性烯醇化酶和嗜铬粒蛋白免疫组化的结果。
