Karamanolis Georgios P, Tack Jan
Gastroenterology Unit, 2 Surgical Department, Aretaieion Hospital, Athens Medical School, Athens, Greece (Georgios P. Karamanolis).
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium (Jan Tack).
Ann Gastroenterol. 2012;25(2):96-99.
Functional dyspepsia (FD) is a highly prevalent disease characterized by symptoms originating from the gastroduodenal region in the absence of underlying organic disease. The Rome III consensus made a distinction between meal-induced and meal-unrelated symptoms and proposed subdivision of FD into postprandial distress syndrome and epigastric pain syndrome. The applicability of this subdivision and the impact on management are areas of active research. So far, empirical approaches are still employed for the treatment of FD, although various therapeutic modalities for FD have been explored; acid-suppressive, prokinetic, and fundic relaxant drugs, antidepressants and psychological therapies. FD remains a challenge and presents unmet clinical needs.
功能性消化不良（FD）是一种高度常见的疾病，其特征为在无潜在器质性疾病的情况下，出现源自胃十二指肠区域的症状。罗马III共识区分了进餐诱发症状和非进餐相关症状，并建议将FD细分为餐后不适综合征和上腹痛综合征。这种细分的适用性及其对治疗的影响是当前积极研究的领域。尽管已经探索了多种针对FD的治疗方式，包括抑酸药、促动力药、胃底松弛剂、抗抑郁药和心理疗法，但迄今为止，FD的治疗仍采用经验性方法。FD仍然是一项挑战，存在未满足的临床需求。
