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本文引用的文献

1
Rifaximin improves psychometric performance and health-related quality of life in patients with minimal hepatic encephalopathy (the RIME Trial).利福昔明可改善轻微肝性脑病患者的心理测量学表现和健康相关生活质量(RIME 试验)。
Am J Gastroenterol. 2011 Feb;106(2):307-16. doi: 10.1038/ajg.2010.455. Epub 2010 Dec 14.
2
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.利福昔明可改善轻微肝性脑病患者随机试验中的驾驶模拟器性能。
Gastroenterology. 2011 Feb;140(2):478-487.e1. doi: 10.1053/j.gastro.2010.08.061. Epub 2010 Sep 21.
3
Drug therapy: rifaximin.药物治疗:利福昔明。
Hepatology. 2010 Oct;52(4):1484-8. doi: 10.1002/hep.23866.
4
EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis.欧洲肝脏研究学会肝硬化腹水、自发性细菌性腹膜炎和肝肾综合征管理临床实践指南
J Hepatol. 2010 Sep;53(3):397-417. doi: 10.1016/j.jhep.2010.05.004. Epub 2010 Jun 1.
5
Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis.己酮可可碱并不能降低晚期肝硬化患者的短期死亡率,但确实能减少并发症。
Gastroenterology. 2010 May;138(5):1755-62. doi: 10.1053/j.gastro.2010.01.040. Epub 2010 Jan 25.
6
Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor.接受类固醇治疗的重症酒精性肝炎患者的感染:治疗的早期反应是关键因素。
Gastroenterology. 2009 Aug;137(2):541-8. doi: 10.1053/j.gastro.2009.04.062. Epub 2009 May 13.
7
Rifaximin versus nonabsorbable disaccharides in the management of hepatic encephalopathy: a meta-analysis.利福昔明与不可吸收双糖治疗肝性脑病的Meta分析
Eur J Gastroenterol Hepatol. 2008 Nov;20(11):1064-70. doi: 10.1097/MEG.0b013e328302f470.
8
Genetic background of Escherichia coli isolates from patients with spontaneous bacterial peritonitis: relationship with host factors and prognosis.自发性细菌性腹膜炎患者分离出的大肠杆菌的遗传背景:与宿主因素及预后的关系
Clin Microbiol Infect. 2008 Nov;14(11):1034-40. doi: 10.1111/j.1469-0691.2008.02088.x.
9
Ciprofloxacin in primary prophylaxis of spontaneous bacterial peritonitis: a randomized, placebo-controlled study.环丙沙星用于自发性细菌性腹膜炎的一级预防:一项随机、安慰剂对照研究。
J Hepatol. 2008 May;48(5):774-9. doi: 10.1016/j.jhep.2008.01.024. Epub 2008 Feb 14.
10
Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis.肝硬化患者食管胃静脉曲张及曲张静脉出血的预防与管理
Hepatology. 2007 Sep;46(3):922-38. doi: 10.1002/hep.21907.

肝硬化患者何时使用抗生素?循证依据。

When to use antibiotics in the cirrhotic patient? The evidence base.

作者信息

Anastasiou Jiannis, Williams Roger

机构信息

Second Department of Gastroenterology, Evangelismos Hospital, Athens, Greece (Jiannis Anastasiou).

Institute of Hepatology, Foundation for Liver Research, London (Roger Williams).

出版信息

Ann Gastroenterol. 2013;26(2):128-131.

PMID:24714766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3959942/
Abstract

Bacterial infections are very common in advanced cirrhosis and are a leading cause of death of these patients. Early and appropriate empirical antibiotic treatment of infection is essential in determining patient's outcome. A strategy of careful restriction of prophylactic antibiotics to the high-risk populations could contribute to the reduction of multidrug resistant bacteria. This article reviews and reports the current knowledge in the use of antibiotics in the cirrhotic patient.

摘要

细菌感染在晚期肝硬化中非常常见,是这些患者死亡的主要原因。对感染进行早期且恰当的经验性抗生素治疗对于决定患者的预后至关重要。对高危人群谨慎限制预防性抗生素的使用策略有助于减少多重耐药菌。本文综述并报告了目前关于肝硬化患者使用抗生素的知识。