Temiz A, Ozcan S, Gökmen F, Gazi E, Barutcu A, Bekler A, Altun B, Akbal A, Güneş F, Şen H
Department of Cardiology, School of Medicine, Çanakkale 18 Mart University, 17110, Çanakkale, Turkey,
Z Rheumatol. 2014 Dec;73(10):934-8. doi: 10.1007/s00393-014-1383-2.
Hypertension (HTN) is common in rheumatoid arthritis (RA) patients. Both HTN and RA have a negative impact on echocardiographically determined parameters including wall thickness, chamber diameter, diastolic function, epicardial adipose tissue (EAT) and carotid intima media thickness (CIMT). We aimed to demonstrate the effect of HTN on these parameters in RA patients.
Patients were divided into two groups: one group comprised 39 RA patients with HTN (7 male, mean age 56.3 ± 8.4 years) and the second comprised 38 age- and gender-matched RA patients without HTN (10 male, mean age 55.3 ± 7.4 years). We retrospectively analyzed the RA patients without overt structural heart disease by determining the study parameters from echocardiograph recordings. The two groups were compared in terms of echocardiographic parameters and disease characteristics.
RA characteristics, chamber sizes and wall thicknesses did not differ between the groups. CIMT was significantly increased in the RA with HTN group (median 0.9 mm, range 0.6-1.2 mm vs. median 0.8 mm, range 0.6-1.0 mm; p = 0.031). EAT was also significantly increased in the RA with HTN group (8.2 ± 1.8 mm vs. 7.4 ± 1.4 mm; p = 0.022). Septal early diastolic E' wave velocities were significantly decreased in the RA with HTN group (8.8 ± 2.4 cm/s vs. 10.2 ± 1.8 cm/s; p = 0.016).
HTN has a further negative impact on diastolic functions, CIMT and EAT in RA patients.
高血压（HTN）在类风湿关节炎（RA）患者中很常见。HTN和RA均对超声心动图测定的参数有负面影响，这些参数包括壁厚度、腔室直径、舒张功能、心外膜脂肪组织（EAT）和颈动脉内膜中层厚度（CIMT）。我们旨在证明HTN对RA患者这些参数的影响。
患者分为两组：一组包括39例患有HTN的RA患者（7例男性，平均年龄56.3±8.4岁），另一组包括38例年龄和性别匹配的无HTN的RA患者（10例男性，平均年龄55.3±7.4岁）。我们通过从超声心动图记录中确定研究参数，对无明显结构性心脏病的RA患者进行回顾性分析。比较两组的超声心动图参数和疾病特征。
两组之间的RA特征、腔室大小和壁厚度没有差异。HTN的RA组CIMT显著增加（中位数0.9mm，范围0.6 - 1.2mm，而中位数0.8mm，范围0.6 - 1.0mm；p = 0.031）。HTN的RA组EAT也显著增加（8.2±1.8mm对7.4±1.4mm；p = 0.022）。HTN的RA组室间隔舒张早期E'波速度显著降低（8.8±2.4cm/s对10.2±1.8cm/s；p = 0.016）。
HTN对RA患者的舒张功能、CIMT和EAT有进一步的负面影响。
