Yamanaka N, Shido F, Kataura A
Department of Otolaryngology, Sapporo Medical College, Japan.
Arch Otorhinolaryngol. 1989;246(2):109-12. doi: 10.1007/BF00457465.
Titers of anti-keratin antibodies (AKA) involving IgG and IgM fractions were determined by a solid-phase enzyme-linked immunsorbent assay (ELISA) and were found to be significantly higher on average in patients with pustulosis palmaris et plantaris (PPP) than in normal controls. Positive rates of IgG-AKA and IgM-AKA in sera of PPP patients were 50% and 66%, respectively. Following tonsillectomies, patients with high IgM-AKA titers that decreased after surgery were found to benefit by a marked improvement in their skin lesions. There was a close relationship between the degree of this improvement in the skin lesions and the changes in IgM-AKA titers after the operation. These results suggest that PPP may be a tonsil-related immunological skin disease.
采用固相酶联免疫吸附测定（ELISA）法测定抗角蛋白抗体（AKA）的IgG和IgM组分滴度，结果发现掌跖脓疱病（PPP）患者的平均滴度显著高于正常对照组。PPP患者血清中IgG-AKA和IgM-AKA的阳性率分别为50%和66%。扁桃体切除术后，发现IgM-AKA滴度高且术后降低的患者，其皮肤病变有明显改善。皮肤病变的改善程度与术后IgM-AKA滴度的变化密切相关。这些结果表明，PPP可能是一种与扁桃体相关的免疫性皮肤病。
