Carroll J C, Blaine S, Permaul J, Dicks E, Warner E, Esplen M J, Rothenmund H, Semotiuk K, Worrall G, McLaughlin J
Department of Family and Community Medicine, Mount Sinai Hospital, University of Toronto, 60 Murray St., Toronto, ON, M5T 3L9, Canada,
J Community Genet. 2014 Oct;5(4):303-11. doi: 10.1007/s12687-014-0185-1. Epub 2014 Apr 9.
We developed a point-of-care tool indicating risk categories for colorectal cancer (CRC) based on family history (FH) and management recommendations tailored to risk. The study objective was to determine if this CRC Risk Triage/Management Too would enable family physicians (FPs) to appropriately triage and make screening and genetics referral recommendations for patients with CRC FH. Baseline questionnaires were mailed to a random sample of FPs in Ontario and Newfoundland, Canada. Participants were asked to use the tool for 3 months and then complete a follow-up questionnaire. The primary outcomes were correct responses to questions regarding CRC risk category, screening method, starting age, frequency, and decision to refer to genetics, for eight clinical vignettes. The study was completed by 75/121 (62 %) participating FPs. Most (77 %) agreed they routinely recommended fecal occult blood testing for average risk patients age ≥50. This did not change significantly following the intervention. There was a significant increase in confidence in CRC risk assessment (52 % pre; 88 % post; p < 0.001), correct management recommendations for patients with CRC FH (51 % pre; 84 % post; p < 0.001), and improvement in total mean scores on outcome measures for all vignettes. Most (90 %) agreed the tool would improve practice. Receipt of the CRC Risk Triage/Management Tool was associated with improvement in FPs' CRC risk assessment, screening, and genetics referral recommendations for clinical vignettes. This demonstrates the value of point-of-care tools and illustrates a process for development, evaluation, and dissemination of tools needed by FPs if potential impacts of genomic advances are to be achieved.
我们开发了一种即时护理工具,该工具基于家族病史(FH)对结直肠癌(CRC)的风险类别进行指示,并针对风险提供量身定制的管理建议。本研究的目的是确定这种CRC风险分类/管理工具能否使家庭医生(FPs)对患有CRC家族病史的患者进行适当的分类,并做出筛查和基因转诊建议。向加拿大安大略省和纽芬兰的FPs随机样本邮寄了基线调查问卷。参与者被要求使用该工具3个月,然后完成一份随访问卷。主要结果是对八个临床病例中关于CRC风险类别、筛查方法、起始年龄、频率以及基因转诊决定等问题的正确回答。75/121(62%)参与研究的FPs完成了该研究。大多数(77%)表示,他们通常会建议年龄≥50岁的平均风险患者进行粪便潜血检测。干预后这一情况没有显著变化。在CRC风险评估方面的信心显著增加(干预前为52%;干预后为88%;p < 0.001),对患有CRC家族病史患者的正确管理建议显著增加(干预前为51%;干预后为84%;p < 0.001),并且所有病例结局指标的总平均分有所提高。大多数(90%)认为该工具会改善临床实践。收到CRC风险分类/管理工具与FPs对临床病例的CRC风险评估、筛查和基因转诊建议的改善相关。这证明了即时护理工具的价值,并说明了如果要实现基因组进展的潜在影响,FPs所需工具的开发、评估和传播过程。