Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, 45239 Essen, Germany.
J Rehabil Med. 2014 Jun;46(6):553-60. doi: 10.2340/16501977-1815.
To determine factors, including pain intensity, associated with pressure pain sensitivity in chronic non-specific neck pain and with changes after therapeutic interventions.
This re-analysis used pooled data from 7 randomized controlled clinical trials. Pressure pain thresholds were assessed at the hand and at the site of maximal pain in the neck region before and after different non-pharmacological interventions. Age, gender, neck pain intensity and duration, mental health, expectancy and time interval between measurements were used to determine factors influencing pressure pain thresholds as well as pressure pain threshold changes.
A total of 346 patients (77 males, 269 females, mean age 52.6 years (standard deviation 12.0 years)) were included in study, 306 of whom provided a complete data-set for analysis. Pressure pain thresholds at the neck area or the hand did not correlate with pain intensity. Changes in pressure pain thresholds correlated with time between measurements, indicating time-sensitive changes.
No coherent correlations between pressure pain thresholds and pain intensity were found. Further research is needed to evaluate the relationship between pain intensity and pressure pain thresholds before its use as a valid substitute of pain rating can be supported. Until then, the results of trials with respect to using pressure pain thresholds as an outcome variable must be interpreted with care.
确定与慢性非特异性颈痛的压痛敏度相关的因素，包括疼痛强度，以及治疗干预后的变化。
本重新分析使用了 7 项随机对照临床试验的汇总数据。在接受不同非药物干预之前和之后，在手和颈部疼痛最严重部位评估压痛阈值。使用年龄、性别、颈痛强度和持续时间、心理健康、预期和测量之间的时间间隔来确定影响压痛阈值以及压痛阈值变化的因素。
共有 346 名患者（77 名男性，269 名女性，平均年龄 52.6 岁（标准差 12.0 岁））纳入研究，其中 306 名患者提供了完整的数据集进行分析。颈部区域或手部的压痛阈值与疼痛强度无关。压痛阈值的变化与测量之间的时间相关，表明存在时间敏感的变化。
未发现压痛阈值与疼痛强度之间存在一致的相关性。在将其用作疼痛评分的有效替代物之前，需要进一步研究评估疼痛强度与压痛阈值之间的关系。在那之前，必须谨慎解释使用压痛阈值作为结局变量的试验结果。
