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Sex differences in pain: a brief review of clinical and experimental findings.性别与疼痛差异：临床与实验研究的简要综述。
Br J Anaesth. 2013 Jul;111(1):52-8. doi: 10.1093/bja/aet127.
2
Reliability and validity study of a Thai version of the Neck Disability Index in patients with neck pain.泰语版颈部残疾指数在颈部疼痛患者中的信效度研究。
J Med Assoc Thai. 2012 May;95(5):681-8.
3
Experimental approaches in the study of pain in the elderly.老年人疼痛研究中的实验方法。
Pain Med. 2012 Apr;13 Suppl 2:S44-50. doi: 10.1111/j.1526-4637.2012.01326.x.
4
Thermal detection and pain thresholds but not pressure pain thresholds are correlated with psychological factors in women with chronic whiplash-associated pain.慢性颈挥鞭样损伤相关性疼痛女性的热感觉和痛觉阈值与心理因素相关，但压力痛觉阈值与心理因素不相关。
Clin J Pain. 2012 Mar-Apr;28(3):211-21. doi: 10.1097/AJP.0b013e318226c3fd.
5
Validation of Thai versions of the Neck Disability Index and Neck Pain and Disability Scale in patients with neck pain.验证 Thai 版本的 Neck Disability Index 和 Neck Pain and Disability Scale 在患有颈部疼痛的患者中的有效性。
Spine (Phila Pa 1976). 2011 Oct 1;36(21):E1415-21. doi: 10.1097/BRS.0b013e31820e68ac.
6
Supra-threshold scaling, temporal summation, and after-sensation: relationships to each other and anxiety/fear.阈上标度、时间总和和后感觉：彼此之间以及与焦虑/恐惧的关系。
J Pain Res. 2010 Mar 31;3:25-32. doi: 10.2147/jpr.s9462.
7
Pain sensitivity and pain reactivity in osteoarthritis.骨关节炎的疼痛敏感性和疼痛反应性。
Arthritis Care Res (Hoboken). 2011 Mar;63(3):320-7. doi: 10.1002/acr.20373. Epub 2010 Oct 18.
8
Exploration of somatosensory impairments in subjects with mechanical idiopathic neck pain: a preliminary study.机械性特发性颈部疼痛患者的躯体感觉障碍探索：一项初步研究。
J Manipulative Physiol Ther. 2010 Sep;33(7):493-9. doi: 10.1016/j.jmpt.2010.08.022.
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Suprathreshold heat pain response is associated with clinical pain intensity for patients with shoulder pain.阈上热痛反应与肩痛患者的临床疼痛强度相关。
J Pain. 2011 Jan;12(1):133-40. doi: 10.1016/j.jpain.2010.06.002. Epub 2010 Aug 7.
10
Bilateral mechanical-pain sensitivity over the trigeminal region in patients with chronic mechanical neck pain.慢性机械性颈痛患者三叉神经区域的双侧机械性疼痛敏感性。
J Pain. 2010 Mar;11(3):256-63. doi: 10.1016/j.jpain.2009.07.003. Epub 2009 Nov 27.

慢性颈痛老年女性的疼痛敏感性改变。

Altered pain sensitivity in elderly women with chronic neck pain.

作者信息

Uthaikhup Sureeporn, Prasert Romchat, Paungmali Aatit, Boontha Kritsana

机构信息

Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Back, Neck and Other Joint Pain Research Group, Khon Kaen University, Khon Kaen, Thailand.

Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

出版信息

PLoS One. 2015 Jun 3;10(6):e0128946. doi: 10.1371/journal.pone.0128946. eCollection 2015.

DOI:10.1371/journal.pone.0128946
PMID:26039149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4454693/
Abstract

BACKGROUND

Age-related changes occur in both the peripheral and central nervous system, yet little is known about the influence of chronic pain on pain sensitivity in older persons. The aim of this study was to investigate pain sensitivity in elders with chronic neck pain compared to healthy elders.

METHODS

Thirty elderly women with chronic neck pain and 30 controls were recruited. Measures of pain sensitivity included pressure pain thresholds, heat/cold pain thresholds and suprathreshold heat pain responses. The pain measures were assessed over the cervical spine and at a remote site, the tibialis anterior muscle.

RESULTS

Elders with chronic neck pain had lower pressure pain threshold over the articular pillar of C5-C6 and decreased cold pain thresholds over the cervical spine and tibialis anterior muscle when compared with controls (p < 0.05). There were no between group differences in heat pain thresholds and suprathreshold heat pain responses (p > 0.05).

CONCLUSION

The presence of pain hypersensitivity in elderly women with chronic neck pain appears to be dependent on types of painful stimuli. This may reflect changes in the peripheral and central nervous system with age.

摘要

背景

外周和中枢神经系统都会出现与年龄相关的变化，但关于慢性疼痛对老年人疼痛敏感性的影响，我们知之甚少。本研究的目的是调查与健康老年人相比，患有慢性颈部疼痛的老年人的疼痛敏感性。

方法

招募了30名患有慢性颈部疼痛的老年女性和30名对照者。疼痛敏感性测量包括压力痛阈、热/冷痛阈和阈上热痛反应。在颈椎和一个较远部位，即胫骨前肌，对疼痛指标进行评估。

结果

与对照组相比，患有慢性颈部疼痛的老年人在C5-C6关节突上的压力痛阈较低，在颈椎和胫骨前肌上的冷痛阈降低（p < 0.05）。两组在热痛阈和阈上热痛反应方面没有差异（p > 0.05）。

结论

患有慢性颈部疼痛的老年女性中疼痛超敏反应的存在似乎取决于疼痛刺激的类型。这可能反映了随着年龄增长外周和中枢神经系统的变化。