Department of Chemical Engineering, West Virginia University, Morgantown, WV, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jul-Aug;6(4):327-37. doi: 10.1002/wnan.1268. Epub 2014 Apr 8.
Based on their physicochemical properties that allow efficient functionalization with biomolecules and cellular membrane translocation, as well as on their applications in Raman and near-infrared fluorescence imaging, carbon nanotubes (CNTs) have been proposed as viable candidates for developing therapeutic platforms that ensure targeting of tumor cells without affecting healthy cells. This article reviews the research on toxicological effects of CNTs on host cells, as well as their pharmacological profiles on cancer cells. The potential impact of this approach is discussed along with some potential pitfalls that will need to be overcome when therapeutic implementation CNTs are considered. For further resources related to this article, please visit the WIREs website.
The authors declare no competing financial interest.
基于允许与生物分子和细胞膜转位有效功能化的物理化学性质,以及在拉曼和近红外荧光成像中的应用,碳纳米管 (CNT) 已被提议作为开发治疗平台的可行候选物,以确保靶向肿瘤细胞而不影响健康细胞。本文综述了 CNT 对宿主细胞的毒理学影响以及它们对癌细胞的药理学特征的研究。讨论了这种方法的潜在影响,以及在考虑使用 CNT 进行治疗时需要克服的一些潜在问题。有关本文的更多资源,请访问 WIREs 网站。
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