沙利度胺联合新辅助化疗治疗完全病理缓解的乳腺血管肉瘤：病例报告及文献复习。
Thalidomide combined with neoadjuvant chemotherapy in angiosarcoma of the breast with complete pathologic response: case report and review of literature.
机构信息
Medical Oncology Department, National Cancer Institute (INCan), Mexico City, Mexico.
Pathology Department, National Cancer Institute (INCan), Mexico City, Mexico.
出版信息
Breast Care (Basel). 2013 Mar;8(1):74-6. doi: 10.1159/000346822.
Abstract
BACKGROUND
Primary angiosarcoma of the breast is a rare malignancy.
CASE REPORT
We report on a 41-year-old female patient who initially presented with locally advanced disease. Core biopsy showed angiosarcoma of the breast, grade 1, CD31-positive. The patient was treated with neoadjuvant systemic chemotherapy based on cisplatin, doxorubicin, and paclitaxel, given concurrently with thalidomide. After treatment completion, the patient underwent radical mastectomy. Pathologic complete response in the breast and axillary lymph nodes was achieved. The patient has no evidence of disease recurrence 6 months after her initial diagnosis.
CONCLUSION
Anti-angiogenic therapy may be considered as part of the management of primary angiosarcoma of the breast.
摘要
背景
原发性乳腺血管肉瘤是一种罕见的恶性肿瘤。
病例报告
我们报告了一例 41 岁女性患者，最初表现为局部晚期疾病。核心活检显示乳腺血管肉瘤，1 级，CD31 阳性。患者接受了基于顺铂、多柔比星和紫杉醇的新辅助全身化疗，并同时给予沙利度胺。治疗完成后，患者接受了根治性乳房切除术。乳腺和腋窝淋巴结达到病理完全缓解。患者在最初诊断后 6 个月无疾病复发迹象。
结论
抗血管生成治疗可考虑作为原发性乳腺血管肉瘤治疗的一部分。
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