用于治疗血管肉瘤的抗血管生成疗法：临床最新进展
Anti-angiogenic therapies for the treatment of angiosarcoma: a clinical update.
作者信息
Young Robin J, Woll Penella J
机构信息
Academic Unit of Clinical Oncology, Weston Park Hospital, Whitham Rd, S10 2SJ Sheffield, United Kingdom.
出版信息
Memo. 2017;10(4):190-193. doi: 10.1007/s12254-017-0365-x. Epub 2017 Nov 7.
Abstract
Angiosarcomas are rare aggressive endothelial tumours, and are associated with a poor prognosis. Due to their vascular nature, there is great interest in their response to anti-angiogenic agents. A number of small prospective studies have reported angiosarcoma response to vascular-targeted agents, including agents that target vascular endothelial growth factor. To date, the response to these agents has been disappointing, and similar to the response observed in other soft tissue sarcoma subtypes. This short review will summarise the recent data in this field.
摘要
血管肉瘤是罕见的侵袭性内皮肿瘤，预后较差。由于其血管特性，人们对其对抗血管生成药物的反应极为关注。一些小型前瞻性研究报告了血管肉瘤对血管靶向药物的反应，包括靶向血管内皮生长因子的药物。迄今为止，这些药物的反应令人失望，与其他软组织肉瘤亚型中观察到的反应相似。这篇简短的综述将总结该领域的最新数据。
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