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一名银质沉着病患者的严重急性放射性皮炎

Severe acute radiation dermatitis in a patient with argyria.

作者信息

Gorayski P, Pinkham M B, Muir J B, Pullar A P

机构信息

Radiation Oncology, Mater Centre, South Brisbane, QLD 4101, Australia ; University of Queensland, St Lucia, QLD 4067, Australia.

Department of Dermatology, Mater Adults Hospital, South Brisbane, QLD 4101, Australia.

出版信息

Case Rep Oncol Med. 2014;2014:154349. doi: 10.1155/2014/154349. Epub 2014 Mar 3.

DOI:10.1155/2014/154349
PMID:24716038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3970361/
Abstract

Argyria is a rare cutaneous condition due to dermal silver deposition leading to irreversible blue-grey discoloration. Acute radiation dermatitis (RD) is an expected toxicity in patients undergoing radiotherapy but it is unknown to what extent argyria affects the onset and severity of RD. We report a patient with argyria treated with concurrent chemoradiotherapy for Merkel cell carcinoma who experienced an unexpectedly brisk and severe RD during treatment. Possible mechanisms for this interaction are considered.

摘要

银质沉着病是一种罕见的皮肤疾病,由于真皮内银沉积导致不可逆的蓝灰色色素沉着。急性放射性皮炎(RD)是接受放疗患者预期会出现的一种毒性反应,但银质沉着病在多大程度上影响放射性皮炎的发生和严重程度尚不清楚。我们报告了一名患有银质沉着病的患者,其因默克尔细胞癌接受同步放化疗,在治疗期间出现了意外迅速且严重的放射性皮炎。本文考虑了这种相互作用的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/101490338540/CRIONM2014-154349.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/2fa29aad6fcf/CRIONM2014-154349.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/0ac0d72a6d9f/CRIONM2014-154349.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/101490338540/CRIONM2014-154349.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/2fa29aad6fcf/CRIONM2014-154349.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/0ac0d72a6d9f/CRIONM2014-154349.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e247/3970361/101490338540/CRIONM2014-154349.003.jpg

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引用本文的文献

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J Clin Med. 2021 May 13;10(10):2086. doi: 10.3390/jcm10102086.

本文引用的文献

1
Silver nanoparticles: a novel radiation sensitizer for glioma?银纳米粒子:胶质瘤的新型辐射增敏剂?
Nanoscale. 2013 Dec 7;5(23):11829-36. doi: 10.1039/c3nr01351k. Epub 2013 Oct 15.
2
The important role of radiation treatment in the management of Merkel cell carcinoma.放射治疗在 Merkel 细胞癌治疗中的重要作用。
Br J Dermatol. 2013 Nov;169(5):975-82. doi: 10.1111/bjd.12481.
3
Ag nanoparticles sensitize IR-induced killing of cancer cells.银纳米颗粒可增强红外线诱导的癌细胞杀伤作用。
Cell Res. 2009 Aug;19(8):1031-4. doi: 10.1038/cr.2009.89.
4
Weekly carboplatin reduces toxicity during synchronous chemoradiotherapy for Merkel cell carcinoma of skin.每周一次的卡铂可降低皮肤默克尔细胞癌同步放化疗期间的毒性。
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1070-4. doi: 10.1016/j.ijrobp.2008.02.076. Epub 2008 Aug 15.
5
Radiotherapy in setting of collagen vascular disease.胶原血管病背景下的放射治疗。
Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1347-53. doi: 10.1016/j.ijrobp.2007.07.2357.
6
Exposure-related health effects of silver and silver compounds: a review.银及银化合物与暴露相关的健康影响:综述
Ann Occup Hyg. 2005 Oct;49(7):575-85. doi: 10.1093/annhyg/mei019. Epub 2005 Jun 17.