Gorayski P, Pinkham M B, Muir J B, Pullar A P
Radiation Oncology, Mater Centre, South Brisbane, QLD 4101, Australia ; University of Queensland, St Lucia, QLD 4067, Australia.
Department of Dermatology, Mater Adults Hospital, South Brisbane, QLD 4101, Australia.
Case Rep Oncol Med. 2014;2014:154349. doi: 10.1155/2014/154349. Epub 2014 Mar 3.
Argyria is a rare cutaneous condition due to dermal silver deposition leading to irreversible blue-grey discoloration. Acute radiation dermatitis (RD) is an expected toxicity in patients undergoing radiotherapy but it is unknown to what extent argyria affects the onset and severity of RD. We report a patient with argyria treated with concurrent chemoradiotherapy for Merkel cell carcinoma who experienced an unexpectedly brisk and severe RD during treatment. Possible mechanisms for this interaction are considered.
银质沉着病是一种罕见的皮肤疾病,由于真皮内银沉积导致不可逆的蓝灰色色素沉着。急性放射性皮炎(RD)是接受放疗患者预期会出现的一种毒性反应,但银质沉着病在多大程度上影响放射性皮炎的发生和严重程度尚不清楚。我们报告了一名患有银质沉着病的患者,其因默克尔细胞癌接受同步放化疗,在治疗期间出现了意外迅速且严重的放射性皮炎。本文考虑了这种相互作用的可能机制。