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Mucuna pruriens 中的神奇天鹅绒豆。

The Magic Velvet Bean of Mucuna pruriens.

机构信息

Department of Chemistry, University of Siena, Italy.

Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Italy.

出版信息

J Tradit Complement Med. 2012 Oct;2(4):331-9. doi: 10.1016/s2225-4110(16)30119-5.

DOI:10.1016/s2225-4110(16)30119-5
PMID:24716148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3942911/
Abstract

Mucuna pruriens (Fabaceae) is an established herbal drug used for the management of male infertility, nervous disorders, and also as an aphrodisiac. It has been shown that its seeds are potentially of substantial medicinal importance. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things as Parkinson's disease. M. pruriens has been shown to have anti-parkinson and neuroprotective effects, which may be related to its anti-oxidant activity. In addition, anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. In this review the medicinal properties of M. pruriens are summarized, taking in consideration the studies that have used the seeds extracts and the leaves extracts.

摘要

Mucuna pruriens(豆科)是一种已被确立的草药,用于治疗男性不育、神经紊乱,也被用作春药。已经表明,它的种子具有重要的药用价值。古印度医学体系阿育吠陀传统上使用 M. pruriens,甚至可以治疗帕金森病等疾病。M. pruriens 已被证明具有抗帕金森病和神经保护作用,这可能与其抗氧化活性有关。此外,M. pruriens 的抗氧化活性也通过其清除 DPPH 自由基和活性氧的能力在体外得到证实。在本综述中,考虑到使用种子提取物和叶子提取物的研究,总结了 M. pruriens 的药用特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c3/3942911/d40572f081c6/JTCM-2-331-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c3/3942911/d40572f081c6/JTCM-2-331-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4c3/3942911/d40572f081c6/JTCM-2-331-g001.jpg

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Phytother Res. 2012 Dec;26(12):1913-9. doi: 10.1002/ptr.4663. Epub 2012 Mar 23.
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The belonging of gpMuc, a glycoprotein from Mucuna pruriens seeds, to the Kunitz-type trypsin inhibitor family explains its direct anti-snake venom activity.来自黎豆种子的糖蛋白 gpMuc 归属于 Kunitz 型胰蛋白酶抑制剂家族,这解释了它的直接抗蛇毒活性。
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Proteomic analysis of the pathophysiological process involved in the antisnake venom effect of Mucuna pruriens extract.
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Front Nutr. 2025 Apr 9;12:1487786. doi: 10.3389/fnut.2025.1487786. eCollection 2025.
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Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia.帕金森病中刺蒺藜与传统左旋多巴的疗效比较:一项来自亚洲的关于药代动力学和临床观点的随机对照试验。
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Drugs from poisonous plants: Ethnopharmacological relevance to modern perspectives.来自有毒植物的药物:民族药理学与现代观点的关联。
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PLoS One. 2024 Dec 6;19(12):e0311140. doi: 10.1371/journal.pone.0311140. eCollection 2024.
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Phytochemicals in Parkinson's Disease: a Pathway to Neuroprotection and Personalized Medicine.帕金森病中的植物化学物质:神经保护和个性化医疗之路
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