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超越药物:利用植物化合物开发抗炎疗法。

Beyond Pharmaceuticals: Harnessing the Potential of Plant-based Compounds for Anti-inflammatory Therapy.

机构信息

Guru Gobind Singh College of Pharmacy, Yamuna Nagar (135001) Haryana, India.

出版信息

Recent Adv Inflamm Allergy Drug Discov. 2024;18(2):90-107. doi: 10.2174/0127722708292961240508110207.

Abstract

A complicated biological reaction of vascular tissues to damaging stimuli like infections, harmed cells, or irritants is called inflammation. Symptoms include redness, inflamed joints, stiffness, discomfort in the joints, and loss of joint function. NSAIDs are frequently used to treat inflammation. Sadly, these drugs raise the possibility of blood clots, which can result in heart attacks and strokes. Consequently, there is ongoing research focusing on developing potent anti-inflammatory drugs using natural ingredients. Natural products, due to their diverse chemical composition, offer a rich source for the development of novel medications. The treatment of various inflammation- related disorders heavily relies on a natural substance derived from medicinal plants. The objective of the present study is to assemble information on potential parts of the plants or phytochemicals derived from medicinal plants used on inflammatory models, employing state-ofthe- art scientific methodologies. In this study, state-of-the-art scientific methodologies are utilized to investigate the effects of phytochemicals derived from medicinal plants. Relevant data is collected, focusing on the examination of these phytochemicals in experimental models of inflammation. The study aims to collect thorough data on potential plant parts or promising phytochemicals derived from medicinal plants that have been evaluated using advanced scientific techniques in the realm of inflammation models. This compilation will offer valuable insights into their potential as anti-inflammatory agents. The findings have the potential to contribute to the development of new and improved anti-inflammatory medications with fewer or no adverse effects compared to current treatments. While many of these studies hold academic interest only a few are accepted into clinical trials. Numerous phytoconstituents have been identified for exhibiting diverse pharmacological actions.

摘要

血管组织对感染、受损细胞或刺激物等损伤性刺激的复杂生物学反应称为炎症。其症状包括发红、关节肿胀、僵硬、关节不适以及关节功能丧失。非甾体抗炎药(NSAIDs)常用于治疗炎症。不幸的是,这些药物增加了血栓形成的可能性,从而导致心脏病发作和中风。因此,目前正在进行研究,重点是使用天然成分开发有效的抗炎药物。由于其多样化的化学成分,天然产物为开发新型药物提供了丰富的来源。许多天然物质来源于药用植物,被广泛应用于治疗各种炎症相关疾病。本研究旨在收集有关药用植物来源的植物部分或植物化学物质在炎症模型中的应用信息,采用最先进的科学方法。在这项研究中,使用最先进的科学方法来研究药用植物来源的植物化学物质的作用。收集了相关数据,重点研究这些植物化学物质在炎症实验模型中的作用。本研究旨在收集全面的数据,了解在炎症模型中使用先进科学技术评估的具有潜在作用的植物部分或有前途的植物化学物质。这一汇编将为它们作为抗炎剂的潜力提供有价值的见解。与当前的治疗方法相比,这些发现有可能促进开发新的、改进的抗炎药物,这些药物的不良反应更少或没有。虽然这些研究中有许多仅具有学术意义,但只有少数被纳入临床试验。已经确定了许多植物成分具有不同的药理作用。

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