Rossini P M, Babiloni F, Bernardi G, Cecchi L, Johnson P B, Malentacca A, Stanzione P, Urbano A
Istituto di Fisiologia Umana, I Cattedra, Università degli Studi di Roma La Sapienza, Italy.
Electroencephalogr Clin Neurophysiol. 1989 Jul-Aug;74(4):277-89. doi: 10.1016/0168-5597(89)90058-0.
Twenty-two patients (16 affected by parkinsonian syndromes, 6 by other neurological diseases) and 12 age-matched controls were examined. Short-latency somatosensory evoked potentials were recorded from 30 scalp electrodes in the 45-52 msec following separate left and right median nerve stimulation at the wrist. Bit-colour maps were generated on a 4096 pixel matrix via quadratic interpolation. Peak latencies and amplitudes of the parietal, central and frontal components were evaluated. Moreover, the amplitude ratios between parietal and frontal components on the same hemiscalp and between peaks on homologous right and left scalp districts were taken into account. The unique significant difference between parkinsonians and controls was represented by a depressed frontal N30 wave. This peak was absent in 3 and reduced in 7 out of 16 parkinsonians, with an overall abnormality rate of 47% of the examined arms. Average maps pooling data of parkinsonians and controls confirmed the presence of reduced evoked activity for the whole duration of wave N30 on those mid- and parasagittal frontal districts where this peak is maximally represented in normals. A similar abnormality was found in 1 of the 6 non-parkinsonian neurological patients suffering from a meningioma of the falx compressing the left supplementary motor area. Possible pathophysiology of such wave N30 abnormalities in parkinsonians is discussed.
对22例患者（16例患有帕金森综合征，6例患有其他神经系统疾病）和12名年龄匹配的对照者进行了检查。在腕部分别刺激左侧和右侧正中神经后45 - 52毫秒内，从30个头皮电极记录短潜伏期体感诱发电位。通过二次插值在4096像素矩阵上生成双色图。评估顶叶、中央和额叶成分的峰潜伏期和波幅。此外，还考虑了同一半侧头皮上顶叶和额叶成分之间以及左右同源头皮区域峰值之间的波幅比。帕金森病患者与对照者之间唯一显著的差异表现为额叶N30波降低。16例帕金森病患者中有3例该峰值缺失，7例降低，所检查手臂的总体异常率为47%。汇总帕金森病患者和对照者数据的平均图证实，在正常情况下该峰值最大的那些中矢状面和旁矢状面额叶区域，N30波的整个持续时间内诱发电活动均降低。在6例非帕金森病神经系统疾病患者中，有1例患有压迫左侧辅助运动区的镰旁脑膜瘤，也发现了类似的异常。文中讨论了帕金森病患者中这种N30波异常可能的病理生理学机制。
