Scarpa Filippo, Sabattini Silvia, Bettini Giuliano
Department of Veterinary Medical Sciences, University of Bologna, Ozzano Dell'Emilia, Italy.
Vet Comp Oncol. 2016 Sep;14(3):245-51. doi: 10.1111/vco.12090. Epub 2014 Apr 9.
A cytological grading for mast cell tumours (MCTs) would be highly desirable, allowing to select the most appropriate therapeutic intervention prior to surgery. This study evaluates the applicability on fine-needle aspirations (FNAs) of the novel Kiupel grading system, based on number of mitoses, multinucleated cells, bizarre nuclei and presence of karyomegaly. Fifty consecutive cases with pre-operative cytological diagnosis were included. In cytological specimens, approximately 1000 cells were evaluated, and the histological grade was assessed on the corresponding resected specimens. On cytology, the above parameters were significantly different between histologically low-grade and high-grade tumours (P < 0.001). The cytograding correctly predicted the histological grade in 47 cases (accuracy, 94%; sensitivity, 84.6%; specificity, 97.3%). Two high-grade MCTs (4%) were not detected on cytology. The cytograding can provide helpful insights to assist clinical decisions in most cases. However, the risk of underestimation in a minority of patients represents a limit to the overall utility of the technique.
对肥大细胞瘤（MCT）进行细胞学分级将非常有必要，这有助于在手术前选择最合适的治疗干预措施。本研究评估了基于有丝分裂数、多核细胞、奇异核和核肿大情况的新型Kiupel分级系统在细针穿刺抽吸（FNA）中的适用性。纳入了50例术前有细胞学诊断的连续病例。在细胞学标本中，评估了约1000个细胞，并在相应的切除标本上评估组织学分级。在细胞学上，上述参数在组织学低级别和高级别肿瘤之间存在显著差异（P < 0.001）。细胞分级在47例病例中正确预测了组织学分级（准确率94%；敏感性84.6%；特异性97.3%）。有2例高级别MCT（4%）在细胞学检查中未被检测到。细胞分级在大多数情况下可为临床决策提供有用的见解。然而，少数患者中存在低估风险，这限制了该技术的整体效用。
