QBiotics Group Limited, Yungaburra, Queensland, Australia.
Jemora Consulting, Geelong, Victoria, Australia.
J Vet Intern Med. 2021 Jan;35(1):430-441. doi: 10.1111/jvim.16009. Epub 2021 Jan 12.
Tigilanol tiglate (TT) is a novel small molecule for intratumoral treatment of nonmetastatic mast cell tumors (MCTs) in dogs. In a randomized controlled clinical study, 75% of dogs that received a single TT treatment achieved complete resolution of the MCT by 28 days, with no recurrence in 93% of dogs at 84 days. Critical to TT's efficacy was the area of the wound (tissue deficit) after slough of the necrotic tumor relative to pretreatment tumor volume.
To analyze data collected during the previous study to (a) describe wounds after slough of treated MCTs and (b) identify determinants of wound area and speed of wound healing.
Wound presence, condition, and area were determined from clinical records of 117 dogs over 84 days after a single intratumoral TT treatment.
Tumor slough occurred 3 to 14 days after treatment, exposing granulation tissue in the wound bed. Wound area after tumor slough in general was related to pretreatment tumor volume, with maximal recorded wound area fully evident in 89% of dogs by day 7. In dogs achieving complete tumor resolution, all wounds were left to heal by secondary intention. Bandaging and other wound management interventions only were required in 5 dogs. Time to healing (ie, full re-epithelialization of treatment site) depended on wound area and location on the body, with most wounds being fully healed between 28 and 42 days after treatment.
Wound area and healing after slough of TT-treated tumors follow a consistent clinical pattern for most dogs.
替吉利隆（TT）是一种新型小分子药物，可用于犬非转移性肥大细胞瘤（MCT）的瘤内治疗。在一项随机对照临床试验中，接受单次 TT 治疗的犬中有 75%在 28 天内完全缓解 MCT，93%的犬在 84 天内无复发。TT 疗效的关键是坏死肿瘤脱落（组织缺损）后相对于治疗前肿瘤体积的创面（组织）面积。
分析先前研究中收集的数据，以描述经 TT 治疗的 MCT 脱落后的创面，并确定创面面积和愈合速度的决定因素。
在单次瘤内 TT 治疗后 84 天内，通过 117 只犬的临床记录确定创面的存在、状况和面积。
肿瘤坏死脱落发生在治疗后 3 至 14 天，暴露出创面床的肉芽组织。一般来说，肿瘤坏死脱落后的创面面积与治疗前的肿瘤体积有关，在第 7 天，89%的犬完全显示出最大记录的创面面积。在完全缓解肿瘤的犬中，所有创面均采用二期愈合。仅 5 只犬需要绷带和其他伤口管理干预。愈合时间（即治疗部位的完全上皮化）取决于创面面积和位置，大多数创面在治疗后 28 至 42 天内完全愈合。
大多数犬的 TT 治疗肿瘤坏死脱落后的创面面积和愈合遵循一致的临床模式。
