Paranjpe Mukta, Müller-Goymann Christel C
Institute for Pharmaceutical Technology, TU Braunschweig, Mendelssohnstr. 1, 38106 Braunschweig, Germany.
Int J Mol Sci. 2014 Apr 8;15(4):5852-73. doi: 10.3390/ijms15045852.
Colloidal drug delivery systems have been extensively investigated as drug carriers for the application of different drugs via different routes of administration. Systems, such as solid lipid nanoparticles, polymeric nanoparticles and liposomes, have been investigated for a long time for the treatment of various lung diseases. The pulmonary route, owing to a noninvasive method of drug administration, for both local and systemic delivery of an active pharmaceutical ingredient (API) forms an ideal environment for APIs acting on pulmonary diseases and disorders. Additionally, this route offers many advantages, such as a high surface area with rapid absorption due to high vascularization and circumvention of the first pass effect. Aerosolization or inhalation of colloidal systems is currently being extensively studied and has huge potential for targeted drug delivery in the treatment of various diseases. Furthermore, the surfactant-associated proteins present at the interface enhance the effect of these formulations by decreasing the surface tension and allowing the maximum effect. The most challenging part of developing a colloidal system for nebulization is to maintain the critical physicochemical parameters for successful inhalation. The following review focuses on the current status of different colloidal systems available for the treatment of various lung disorders along with their characterization. Additionally, different in vitro, ex vivo and in vivo cell models developed for the testing of these systems with studies involving cell culture analysis are also discussed.
胶体药物递送系统作为药物载体已被广泛研究，可通过不同给药途径应用不同药物。诸如固体脂质纳米粒、聚合物纳米粒和脂质体等系统，长期以来一直被研究用于治疗各种肺部疾病。肺部给药途径作为一种非侵入性给药方法，对于活性药物成分（API）的局部和全身递送而言，为作用于肺部疾病和病症的API形成了理想环境。此外，该途径具有许多优势，例如由于高血管化而具有高表面积且吸收迅速，并且可避免首过效应。目前，胶体系统的雾化或吸入正在被广泛研究，并且在各种疾病的治疗中具有靶向药物递送的巨大潜力。此外，存在于界面处的表面活性剂相关蛋白通过降低表面张力并实现最大效应来增强这些制剂的效果。开发用于雾化的胶体系统最具挑战性的部分是维持成功吸入所需的关键物理化学参数。以下综述重点关注可用于治疗各种肺部疾病的不同胶体系统的现状及其表征。此外，还讨论了为测试这些系统而开发的不同体外、离体和体内细胞模型以及涉及细胞培养分析的研究。
