Strader C H, Vaughan T L, Stergachis A
Hanford Environmental Health Foundation, Richland, Washington 99352.
J Epidemiol Community Health. 1988 Sep;42(3):243-8. doi: 10.1136/jech.42.3.243.
Data from a population based case control study in western Washington were analysed to determine whether the use of nasal sprays and drops was associated with an increased risk of sinonasal cancer. Telephone interviews were conducted with incident cases (n = 53) diagnosed between 1979 and 1983 or their next-of-kin, and with controls (n = 552) regarding their past use of nasal preparations, history of rhinologic problems, smoking history, alcohol consumption, and a number of other known or suspected risk factors. Both cigarette smoking and alcohol consumption were associated with an increased risk of sinonasal cancer; the strongest associations were found with squamous cell tumours. Subjects who reported a history of nasal preparation use were 3.5 times (95% confidence interval = 1.7-7.0) more likely than non-users to develop sinonasal cancer. The risk of sinonasal cancer increased with increasing duration of use of nasal preparations. These findings suggest the need for a more detailed investigation of the possible adverse consequences of long-term use of nasal preparations.
对华盛顿州西部一项基于人群的病例对照研究数据进行了分析，以确定使用鼻喷雾剂和滴鼻剂是否与鼻窦癌风险增加有关。对1979年至1983年间确诊的53例新发病例或其近亲进行了电话访谈，并对552名对照者进行了电话访谈，询问他们过去使用鼻腔制剂的情况、鼻科疾病史、吸烟史、饮酒情况以及其他一些已知或疑似的风险因素。吸烟和饮酒均与鼻窦癌风险增加有关；鳞状细胞肿瘤的相关性最强。报告有鼻腔制剂使用史的受试者患鼻窦癌的可能性是非使用者的3.5倍（95%置信区间=1.7-7.0）。鼻窦癌风险随着鼻腔制剂使用时间的延长而增加。这些发现表明需要对长期使用鼻腔制剂可能产生的不良后果进行更详细的调查。
