Al-Mohizea Abdullah M, Ahad Abdul, El-Maghraby Gamal M, Al-Jenoobi Fahad I, AlKharfy Khalid M, Al-Suwayeh Saleh A
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):219-24. doi: 10.1007/s13318-014-0199-4. Epub 2014 Apr 11.
The present study was conducted to investigate the effects of some commonly used herbs namely Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on the pharmacokinetics of sildenafil in beagle dogs. The study design involved four treatments in a non-balanced crossover design. Sildenafil was given one tablet 100 mg orally to each dog and blood samples were obtained. After a suitable washout period, animals were commenced on a specific herb treatment for 1 week. Blood samples were withdrawn at different time intervals and sildenafil was analyzed by HPLC method. Oral administration of Nigella sativa resulted in reduction of AUC0-∞, C max and t 1/2 as compared to the control. Treatment of Lepidium sativum resulted in a significant reduction in the C max and AUC. There were no significant differences between the rests of the pharmacokinetic parameters relative to those of the control. For Trigonella foenum-graecum, the effects were similar to those obtained in case of Lepidium sativum. It was concluded that concurrent use of investigated herbs alters the pharmacokinetics of sildenafil. Co-administration of investigated herbs should be cautious since their concomitant use might result in decrease in sildenafil bioavailability.
本研究旨在探讨一些常用草药，即黑种草、独行菜和胡芦巴对西地那非在比格犬体内药代动力学的影响。研究设计采用非平衡交叉设计的四种处理方式。给每只犬口服一片100毫克的西地那非，并采集血样。经过适当的洗脱期后，动物开始接受特定草药治疗1周。在不同时间间隔采集血样，并用高效液相色谱法分析西地那非。与对照组相比，口服黑种草导致AUC0-∞、Cmax和t1/2降低。独行菜治疗导致Cmax和AUC显著降低。其余药代动力学参数与对照组相比无显著差异。对于胡芦巴，其效果与独行菜相似。得出的结论是，同时使用所研究的草药会改变西地那非的药代动力学。由于同时使用所研究的草药可能会导致西地那非生物利用度降低，因此联合用药应谨慎。
