Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Phytother Res. 2013 Dec;27(12):1800-4. doi: 10.1002/ptr.4947. Epub 2013 Feb 11.
The present work was designed to evaluate the effect of some commonly used herbs viz. garden cress (Lepidium sativum), black seed (Nigella sativa) and fenugreek (Trigonella foenum-graceum) on the disposition of phenytoin after oral administration in a dog model. Phenytoin was given orally at a dose of 50 mg, and blood samples were obtained for the determination of drug's pharmacokinetic parameters. After a suitable washout period, animals were commenced on a specific herb treatment for one week. Garden cress treatment caused a modest increase in maximum observed concentration (Cmax ) and terminal half-life (T1/2λ ) of phenytoin with a reduction in clearance by 33%. The effect of black seed therapy was more drastic on drug elimination and to a lesser extent on its volume of distribution at steady state (Vss ) with a consequent reduction in systemic exposure measured by area under the curve (AUC0-∞ ) by about 87%. The effect of fenugreek therapy resembled, albeit to a lesser extent, that of black seed with a significant reduction in AUC0-∞ by ~72%. In addition, there was a 73% increase in Vss . Our findings suggest that the phenytoin disposition can be significantly altered by the concurrent consumption of tested herbal products.
本研究旨在评估一些常用草药（如荠、黑种草和胡芦巴）对犬模型中口服苯妥英后苯妥英 disposition 的影响。给予苯妥英 50mg 口服剂量，并采集血样以确定药物的药代动力学参数。经过适当的洗脱期后，动物开始接受特定草药治疗一周。荠处理导致苯妥英的最大观测浓度 (Cmax) 和末端半衰期 (T1/2λ) 适度增加，清除率降低 33%。黑种草治疗对药物消除的影响更为剧烈，对稳态时分布容积 (Vss) 的影响较小，从而导致 AUC0-∞ （曲线下面积）的全身暴露降低约 87%。胡芦巴治疗的作用类似于黑种草，但 AUC0-∞ 显著降低约 72%。此外，Vss 增加了 73%。我们的研究结果表明，同时服用测试的草药产品可能会显著改变苯妥英的 disposition。
