Zhang Binbin, Lv Ming, Chen Tiantian, Wei Qizhen, Wang Guochang, Tian Jing, Chen Bo
Hepatogastroenterology. 2013 Nov-Dec;60(128):1922-6.
BACKGROUND/AIMS: To describe the detail of lymph node dissection and its number and to study the association between that and the postoperative survival in patients with colorectal cancer.
Two hundred and sixty-five patients with colorectal cancer performed radical resection from December 2004 to December 2006 in the Department of General Surgery, Qilu Hospital of Shandong University were analyzed. The survival rate was estimated using Kaplan-Meier methodology. Log-rank test was used for significant comparison and Cox proportional hazards regression was used to multivariately assess outcome.
The survival rate of colorectal cancer patients who had 12 or more lymph nodes harvested was significantly higher than that of those who had less than 12 lymph nodes harvested (adjusted risk ratio (RR): 0.215; 95% CI: 0.102-0.456). The number of lymph nodes harvested was a significant variable that affected survival in both stage II and stage III patients. Only 24.9% of all patients had at least 12 lymph nodes harvested.
The number of lymph nodes harvested was a prognostic variable to evaluate outcome in patients with colorectal cancer. However, most patients did not receive adequate lymph node evaluation. More efforts should be done to improve quality of care in this area.
背景/目的：描述淋巴结清扫的细节及其数量，并研究其与结直肠癌患者术后生存率之间的关联。
分析2004年12月至2006年12月在山东大学齐鲁医院普通外科接受根治性切除术的265例结直肠癌患者。采用Kaplan-Meier方法估计生存率。使用对数秩检验进行显著性比较，并使用Cox比例风险回归进行多变量评估结果。
清扫出12个或更多淋巴结的结直肠癌患者的生存率显著高于清扫出少于12个淋巴结的患者（调整风险比（RR）：0.215；95%置信区间：0.102 - 0.456）。清扫出的淋巴结数量是影响II期和III期患者生存率的一个显著变量。所有患者中只有24.9%清扫出至少12个淋巴结。
清扫出的淋巴结数量是评估结直肠癌患者预后的一个变量。然而，大多数患者未接受充分的淋巴结评估。应做出更多努力以改善该领域的医疗质量。
