Soubrane G, Coscas G
Rev Prat. 1989 May 11;39(14):1196-200.
Age related macular degeneration (A.R.M.D.) is the first cause of registered blindness in the developed countries after the age of 50. The prevalence of the disease increases with age. Risk factors have been identified. The atrophic form of age related macular degeneration, the most frequent form, results in a moderate decrease in visual acuity. The neovascular form of A.R.M.D. is associated in natural history with a central scotoma within 2 years. The disease involves both eyes with time. Fluorescein angiography allows an accurate diagnosis in identifying the subretinal new-vessels, and their location. The efficiency of blue green argon photocoagulation has been demonstrated on visual acuity by randomised trials, when the new vessels extend at more than 200 microns from the center. For new-vessels closer to it, monochromatic wavelengths can achieve the destruction of the neovascularization. But, laser photocoagulation is not the treatment of the basic process of A.R.M.D.
年龄相关性黄斑变性(A.R.M.D.)是发达国家50岁以后登记失明的首要原因。该疾病的患病率随年龄增长而增加。已确定了风险因素。年龄相关性黄斑变性的萎缩型是最常见的类型,会导致视力中度下降。A.R.M.D.的新生血管型在自然病程中会在2年内出现中心暗点。随着时间推移,该疾病会累及双眼。荧光素血管造影可准确诊断,识别视网膜下新生血管及其位置。当新生血管从中心延伸超过200微米时,随机试验已证明蓝绿氩激光光凝对视力有效。对于更靠近中心的新生血管,单色波长可实现新生血管化的破坏。但是,激光光凝并非年龄相关性黄斑变性基本病程的治疗方法。