Karim Sajjad, Mirza Zeenat, Naseer Muhammad Imran, Al-Qahtani Mohammed Hussain, Ali Arif
Hepatogastroenterology. 2013 Nov-Dec;60(128):2113-8.
BACKGROUND/AIMS: The present study was aimed to investigate the correlation between selected clinicopathological characteristics and p53 protein overexpression, in Indian gastric cancer patients.
Here, we studied specimens from 103 patients with gastric carcinomas and cases were categorized by AJCC-TNM classification. The p53 expression was analyzed in all the specimens by immunohistochemistry (IHC) and was correlated with the clinicopathological characteristics of the patients as well as etiological factors for gastric cancer. The cases were considered p53 overexpressed if more than 25% of the tumor cells were found to be expressing this protein.
We found significant association of p53 overexpression with the gender (p = 0.004) and histology grades (p = 0.001). However, p53 overexpression was not found to be significantly associated with other clinicopathological characteristics like age, cell differentiation, stage and location and various etiological factors.
Our observation showed that IHC-based detection of altered expression of p53 protein in gastric carcinomas may play an important role for diagnosing the progression of gastric carcinoma, even in the early stages.
背景/目的：本研究旨在调查印度胃癌患者特定临床病理特征与p53蛋白过表达之间的相关性。
在此，我们研究了103例胃癌患者的标本，并根据AJCC-TNM分类对病例进行了分类。通过免疫组织化学（IHC）分析所有标本中的p53表达，并将其与患者的临床病理特征以及胃癌的病因因素相关联。如果发现超过25%的肿瘤细胞表达该蛋白，则认为病例存在p53过表达。
我们发现p53过表达与性别（p = 0.004）和组织学分级（p = 0.001）之间存在显著关联。然而，未发现p53过表达与年龄、细胞分化、分期和位置等其他临床病理特征以及各种病因因素有显著关联。
我们的观察表明，基于免疫组织化学检测胃癌中p53蛋白表达改变可能对诊断胃癌进展，甚至早期胃癌进展发挥重要作用。
