Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
J Org Chem. 2014 May 2;79(9):4119-24. doi: 10.1021/jo402550e. Epub 2014 Apr 18.
Intramolecular C-C bond formation of oxygen- and nitrogen-tethered alkynes and epoxide mediated by Lewis acid under ambient conditions is described. A simple procedure for the synthesis of 3,6- and 5,6-dihydropyrans and 3,4-dehydropiperidines from acyclic building blocks in good yields without using any transition metal is shown.
本文描述了在路易斯酸存在下，氧气和氮气键合的炔烃和环氧化物在环境条件下的分子内 C-C 键形成。本文展示了一种从非环构建块中以良好的收率合成 3,6-和 5,6-二氢吡喃和 3,4-脱水哌啶的简单方法，无需使用任何过渡金属。
