Huang Zhigang, Zhang Xie, Lu Hongna, Wu Lina, Wang Danping, Zhang Qiubo, Ding Huaxin
Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, 57# Xingning Road, Ningbo 315000, China.
BMC Gastroenterol. 2014 Apr 11;14:74. doi: 10.1186/1471-230X-14-74.
The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test.
Patients with gastric cancer, chronic atrophic gastritis (CAG) or chronic non-atrophic gastritis (CNAG), and healthy people were recruited. Serum concentrations of TFFs, PG I, and PG II, as well as the presence of antibodies against Helicobacter pylori, were measured by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristics (ROC) were used to compare the predictive powers of the selected factors.
The serum concentrations of TFF1, TFF2, and TFF3 in the control groups were significantly lower than those in the gastric cancer group with the exception of TFF2 which was elevated in CAG. The area under the ROC curve for TFF3 was greater than that for the PG I/II ratio (0.81 vs 0.78). TFF3 also had a significantly higher predictive power for distinguishing gastric cancer than the PG test (odds ratio: 10.33 vs 2.57). Moreover, combining the serum TFF3 and PG tests for gastric cancer had better predictive power than either alone.
Serum TFF3 may be a better predictor of gastric cancer than the PG test, while the combined testing of serum PG and TFF3 could further improve the efficacy of gastric cancer screening.
寻找更好的胃癌非侵入性生物标志物的工作仍在进行中。我们研究了血清三叶因子（TFF）水平作为胃癌生物标志物的预测能力，并与胃蛋白酶原（PG）检测进行比较。
招募了胃癌患者、慢性萎缩性胃炎（CAG）或慢性非萎缩性胃炎（CNAG）患者以及健康人。通过酶联免疫吸附测定（ELISA）测量血清中TFFs、PG I和PG II的浓度，以及抗幽门螺杆菌抗体的存在情况。采用受试者工作特征（ROC）曲线比较所选因素的预测能力。
除CAG中TFF2升高外，对照组血清TFF1、TFF2和TFF3浓度均显著低于胃癌组。TFF3的ROC曲线下面积大于PG I/II比值（0.81对0.78）。TFF3区分胃癌的预测能力也显著高于PG检测（优势比：10.33对2.57）。此外，联合血清TFF3和PG检测对胃癌的预测能力优于单独检测。
血清TFF3可能是比PG检测更好的胃癌预测指标，而血清PG和TFF3联合检测可进一步提高胃癌筛查的效果。
