Moriyama I, Hino K, Ninomiya Y, Nabuchi K, Kato Y, Tsuji Y, Ichijo M
Asia Oceania J Obstet Gynaecol. 1989 Mar;15(1):87-92. doi: 10.1111/j.1447-0756.1989.tb00158.x.
Understanding the hemoglobin switching regulation mechanism in extremely premature infants is particularly important for understanding the extrauterine adaptation of the infants. In this study, we sought to identify factors influencing oxygen affinity in fetal blood and neonatal blood and obtained these results. (1) Aging is required for hemoglobin switching. (2) Switching in premature infants (27 to 32 weeks) is delayed at least 3 weeks in comparison with full-term infants. (3) A delay in the switching of fetal hemoglobin to adult hemoglobin was confirmed in IUGR (intrauterine growth retardation) infants. However, there is a compensatory increase in 2, 3-DPG for adaptation after birth. (4) A delay in 2, 3-DPG increase was observed in RDS (respiratory distress syndrome) infants, and oxygen affinity remained high.
了解极早产儿的血红蛋白转换调节机制对于理解婴儿宫外适应尤为重要。在本研究中，我们试图确定影响胎儿血液和新生儿血液中氧亲和力的因素，并获得了以下结果。（1）血红蛋白转换需要老化过程。（2）与足月儿相比，早产儿（27至32周）的转换延迟至少3周。（3）宫内生长受限（IUGR）婴儿中证实了胎儿血红蛋白向成人血红蛋白转换的延迟。然而，出生后有2,3 -二磷酸甘油酸（2,3-DPG）的代偿性增加以适应。（4）呼吸窘迫综合征（RDS）婴儿中观察到2,3-DPG增加延迟，且氧亲和力仍然很高。
