Chiang Ting-Yen, Tsao Shih-Ming, Yeh Chao-Bin, Yang Shun-Fa
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Clin Chim Acta. 2014 Jun 10;433:272-7. doi: 10.1016/j.cca.2014.03.031. Epub 2014 Apr 8.
Pneumonia is a worldwide infectious disease that is associated with significant morbidity and mortality and is the most common fatal infection acquired in hospitals. Despite advances in preventive strategies, such as antibiotic therapies and intensive care, the mortality rate still requires substantial improvement. Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endopeptidases, which are known as the major enzymes responsible for the proteolytic degradation of proteinaceous components of the extracellular matrix (ECM). Although the main function of MMPs is the removal of the ECM during tissue resorption and progression of various diseases, MMPs also interact with multiple cytokines, participating in the pathology of infection and inflammation. This review presents a schematic overview of the different MMPs expressed in pneumonia. MMPs are key factors in the pathogenesis of various types of pneumonia, such as community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia. Here, we review the pathological roles of various MMPs in pneumonia.
肺炎是一种全球性的传染病，与严重的发病率和死亡率相关，是医院获得性感染中最常见的致命感染。尽管在预防策略方面取得了进展，如抗生素治疗和重症监护，但死亡率仍需大幅改善。基质金属蛋白酶（MMPs）是一大类锌依赖性内肽酶，被认为是负责细胞外基质（ECM）蛋白质成分蛋白水解降解的主要酶。虽然MMPs的主要功能是在组织吸收和各种疾病进展过程中去除ECM，但MMPs也与多种细胞因子相互作用，参与感染和炎症的病理过程。本综述概述了肺炎中表达的不同MMPs。MMPs是各种类型肺炎（如社区获得性肺炎、医院获得性肺炎和呼吸机相关性肺炎）发病机制中的关键因素。在此，我们综述了各种MMPs在肺炎中的病理作用。
