咖啡因对早产呼吸暂停新生儿心率变异性的影响。
The effects of caffeine on heart rate variability in newborns with apnea of prematurity.
作者信息
Ulanovsky I, Haleluya N S, Blazer S, Weissman A
机构信息
Departments of Neonatology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel.
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
J Perinatol. 2014 Aug;34(8):620-3. doi: 10.1038/jp.2014.60. Epub 2014 Apr 10.
OBJECTIVE
Apnea of prematurity is a common complication in premature newborns and caffeine is a widespread medication used to treat this complication. Caffeine may have adverse effects on the cardiovascular and central nervous system, yet its effects on the autonomic nervous system modulation of heart rate have not been studied in premature newborns, which was the objective of our study.
STUDY DESIGN
We prospectively studied 21 premature newborns who were treated with caffeine. We analyzed heart rate variability by power spectral density and by dynamic nonlinear analyses methods.
RESULT
There were no changes in heart rate, blood pressure or the autonomic nervous system tone following administration of caffeine, nor were the nonlinear dynamical properties of the system altered by caffeine.
CONCLUSION
Caffeine does not have detrimental effects on heart rate variability, heart rate or blood pressure in conventional doses given to premature newborns.
目的
早产新生儿呼吸暂停是一种常见并发症，咖啡因是用于治疗该并发症的广泛使用的药物。咖啡因可能对心血管和中枢神经系统有不良影响，但其对早产新生儿心率自主神经系统调节的影响尚未得到研究，这是我们研究的目的。
研究设计
我们前瞻性地研究了21例接受咖啡因治疗的早产新生儿。我们通过功率谱密度和动态非线性分析方法分析心率变异性。
结果
给予咖啡因后，心率、血压或自主神经系统张力没有变化，咖啡因也未改变系统的非线性动力学特性。
结论
给予早产新生儿常规剂量的咖啡因对心率变异性、心率或血压没有有害影响。
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