Department of Food and Environmental Sciences, PO Box 56, 00014 University of Helsinki, Finland.
J Gen Virol. 2014 Jul;95(Pt 7):1415-1429. doi: 10.1099/vir.0.064220-0. Epub 2014 Apr 10.
Potyviruses represent one of the most economically important and widely distributed groups of plant viruses. Despite considerable progress towards understanding the cellular and molecular basis of their pathogenicity, many questions remain about the mechanisms by which potyviruses suppress host defences and create an optimal intracellular environment for viral translation, replication, assembly and spread. The review focuses on the multifunctional roles of potyviral proteins and their interplay with various host factors in different compartments of the infected cell. We place special emphasis on the recently discovered and currently putative mechanisms by which potyviruses subvert the normal functions of different cellular organelles in order to establish an efficient and productive infection.
马铃薯 Y 病毒属代表了植物病毒中最重要且分布最广泛的一类。尽管在了解其致病性的细胞和分子基础方面取得了相当大的进展，但关于马铃薯 Y 病毒属如何抑制宿主防御并为病毒的翻译、复制、组装和传播创造最佳的细胞内环境，仍有许多问题尚未解决。本综述重点介绍了马铃薯 Y 病毒属蛋白的多功能作用及其与受感染细胞不同隔室中各种宿主因子的相互作用。我们特别强调了最近发现的、目前推测的马铃薯 Y 病毒属颠覆不同细胞细胞器正常功能以建立高效和有生产力的感染的机制。
