Department of Ophthalmology, Gachon University, Gil Hospital, Incheon, Korea.
Neuroscience Research Institute, Gachon University, Incheon, Korea.
Invest Ophthalmol Vis Sci. 2014 Apr 10;55(6):3468-76. doi: 10.1167/iovs.14-13902.
To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI).
The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All subjects underwent imaging on a high-resolution 7.0-T MRI system. Bilateral LGNs were identified and manually delineated, and LGN volumes were compared. Peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head parameters (including optic disc size, rim area, and cup-to-disc ratio), and combined thickness of the ganglion cell layer and inner plexus layer (GC-IPL) were measured by Cirrus high-definition optical coherence tomography (OCT). Correlations between OCT parameters and LGN volume were investigated.
Mean LGN volumes were significantly smaller in the POAG group than in the control group (right, glaucoma 83.97 mm(3) [SD ± 26.65] versus control 106.12 mm(3) [SD ± 24.32]; left, glaucoma 65.12 mm(3) [SD ± 29.41] versus control 92.70 mm(3) [SD ± 24.42], both P < 0.05). In the POAG group, average GC-IPL thickness was correlated with contralateral LGN volume (right LGN: r = 0.605, P = 0.008; left LGN: r = 0.471, P = 0.049). The correlation for right LGN volume remained significant after correction for multiple comparisons. However, there was no correlation between LGN volume and average pRNFL thickness or optic disc parameters in the POAG group.
On high-resolution 7.0-T MRI, LGN volumes in POAG patients are significantly smaller than those of healthy subjects. Furthermore, in patients, LGN volume was found to be significantly correlated with GC-IPL thickness of the contralateral eye.
利用超高场 7.0-T 磁共振成像（MRI）研究原发性开角型青光眼（POAG）患者与年龄和性别匹配的对照组之间的外侧膝状体（LGN）体积。
本研究纳入了 18 名 POAG 患者和 18 名年龄和性别匹配的健康志愿者。所有受试者均在高分辨率 7.0-T MRI 系统上进行成像。双侧 LGN 被识别并手动描绘，比较 LGN 体积。通过 Cirrus 高清光学相干断层扫描（OCT）测量视盘周围视网膜神经纤维层（pRNFL）厚度、视神经头参数（包括视盘大小、边缘面积和杯盘比）和节细胞层和内丛状层（GC-IPL）的总和厚度。研究了 OCT 参数与 LGN 体积之间的相关性。
POAG 组的平均 LGN 体积明显小于对照组（右侧，青光眼 83.97mm³[标准差±26.65]与对照组 106.12mm³[标准差±24.32]；左侧，青光眼 65.12mm³[标准差±29.41]与对照组 92.70mm³[标准差±24.42]，均 P<0.05）。在 POAG 组中，平均 GC-IPL 厚度与对侧 LGN 体积呈正相关（右侧 LGN：r=0.605，P=0.008；左侧 LGN：r=0.471，P=0.049）。校正多重比较后，右侧 LGN 体积的相关性仍然显著。然而，在 POAG 组中，LGN 体积与平均 pRNFL 厚度或视盘参数之间没有相关性。
在高分辨率 7.0-T MRI 上，POAG 患者的 LGN 体积明显小于健康受试者。此外，在患者中，LGN 体积与对侧眼的 GC-IPL 厚度显著相关。
