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人血影蛋白中24 kDa血影蛋白重复结构域6的多肽主链、C(β)和甲基基团的共振归属

Polypeptide backbone, C(β) and methyl group resonance assignments of the 24 kDa plectin repeat domain 6 from human protein plectin.

作者信息

Pulavarti Surya Vsrk, Eletsky Alexander, Huang Yuanpeng J, Acton Thomas B, Xiao Rong, Everett John K, Montelione Gaetano T, Szyperski Thomas

机构信息

Department of Chemistry, The State University of New York at Buffalo, and Northeast Structural Genomics Consortium, Buffalo, NY 14260, USA.

Center for Advanced Biotechnology and Medicine and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey and Northeast Structural Genomics Consortium, Piscataway, NJ 08854, USA.

出版信息

Biomol NMR Assign. 2015 Apr;9(1):135-138. doi: 10.1007/s12104-014-9559-x. Epub 2014 Apr 11.

DOI:10.1007/s12104-014-9559-x
PMID:24722902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4194182/
Abstract

The 500 kDa protein plectin is essential for the cytoskeletal organization of most mammalian cells and it is up-regulated in some types of cancer. Here, we report nearly complete sequence-specific polypeptide backbone, (13)C(β) and methyl group resonance assignments for 24 kDa human plectin(4403-4606) containing the C-terminal plectin repeat domain 6.

摘要

500 kDa的纽带蛋白对于大多数哺乳动物细胞的细胞骨架组织至关重要，并且在某些类型的癌症中上调。在此，我们报告了包含C末端纽带蛋白重复结构域6的24 kDa人纽带蛋白（4403 - 4606）的几乎完整的序列特异性多肽主链、（13）C（β）和甲基基团共振归属。

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本文引用的文献

1
Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.由于在胰腺癌中的定位错误，支架蛋白 plectin 获得了意想不到的功能。
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Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.桥粒芯胶中间丝在皮肤、骨骼肌和周围神经中的相互作用。
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NMR structure determination for larger proteins using backbone-only data.使用仅包含骨架数据的方法进行较大蛋白质的 NMR 结构测定。
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5
NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure.嗜热栖热菌蛋白TM1509的核磁共振溶液结构揭示了一种类似锌金属蛋白酶的三级结构。
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6
Ile, Leu, and Val methyl assignments of the 723-residue malate synthase G using a new labeling strategy and novel NMR methods.采用新的标记策略和新型核磁共振方法对723个残基的苹果酸合酶G进行异亮氨酸、亮氨酸和缬氨酸甲基归属。
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7
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.桥粒斑蛋白两个中间丝结合片段的结构揭示了一种独特的重复基序结构。
Nat Struct Biol. 2002 Aug;9(8):612-20. doi: 10.1038/nsb818.
8
Automatic determination of protein backbone resonance assignments from triple resonance nuclear magnetic resonance data.从三重共振核磁共振数据中自动确定蛋白质主链共振归属
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9
Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).人类网蛋白：基因结构、序列分析及染色体定位（8q24）
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4278-83. doi: 10.1073/pnas.93.9.4278.
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High-level production of uniformly ¹⁵N- and ¹³C-enriched fusion proteins in Escherichia coli.在大肠杆菌中高水平生产均匀富集¹⁵N和¹³C的融合蛋白。
J Biomol NMR. 1996 Mar;7(2):131-41. doi: 10.1007/BF00203823.