人血影蛋白中24 kDa血影蛋白重复结构域6的多肽主链、C(β)和甲基基团的共振归属
Polypeptide backbone, C(β) and methyl group resonance assignments of the 24 kDa plectin repeat domain 6 from human protein plectin.
作者信息
Pulavarti Surya Vsrk, Eletsky Alexander, Huang Yuanpeng J, Acton Thomas B, Xiao Rong, Everett John K, Montelione Gaetano T, Szyperski Thomas
机构信息
Department of Chemistry, The State University of New York at Buffalo, and Northeast Structural Genomics Consortium, Buffalo, NY 14260, USA.
Center for Advanced Biotechnology and Medicine and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey and Northeast Structural Genomics Consortium, Piscataway, NJ 08854, USA.
出版信息
Biomol NMR Assign. 2015 Apr;9(1):135-138. doi: 10.1007/s12104-014-9559-x. Epub 2014 Apr 11.
Abstract
The 500 kDa protein plectin is essential for the cytoskeletal organization of most mammalian cells and it is up-regulated in some types of cancer. Here, we report nearly complete sequence-specific polypeptide backbone, (13)C(β) and methyl group resonance assignments for 24 kDa human plectin(4403-4606) containing the C-terminal plectin repeat domain 6.
摘要
500 kDa的纽带蛋白对于大多数哺乳动物细胞的细胞骨架组织至关重要，并且在某些类型的癌症中上调。在此，我们报告了包含C末端纽带蛋白重复结构域6的24 kDa人纽带蛋白（4403 - 4606）的几乎完整的序列特异性多肽主链、（13）C（β）和甲基基团共振归属。
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