Malhotra Rubii, Singh Luxmi, Bundela R K, Garg Pragati, Kant Diva, Garg Ankit, Lal B B
Associate Professor, Ophthalmology Department, Era's Lucknow Medical College & Hospital, Lucknow, India
Professor, Ophthalmology Department, Era's Lucknow Medical College & Hospital, Lucknow, India.
Trop Doct. 2014 Jul;44(3):143-7. doi: 10.1177/0049475514529759. Epub 2014 Apr 10.
To study the retinal changes in subjects suffering from dengue fever and check if these changes can be taken as sufficient indicator of severity and progression of the disease.
PATIENTS/METHODS: A detailed history was recorded of 118 patients on whom ocular examination, including direct ophthalmoscopy, indirect ophthalmoscopy and coloured fundus photography, was performed.
Forty-seven percent of patients were found to have posterior segment abnormalities. Retinal vein dilatation or tortuosity was the most common finding followed by changes in the optic disc (8.4% of patients) and background haemorrhage (6.7% of patients). With increasing severity of thrombocytopenia, the proportion of patients with retinal abnormalities increased. In patients with grade I thrombocytopenia, no fundal abnormality was found. In those with grade II thrombocytopenia, fundal abnormality was found in 13.63% patients, whereas in the grade III category it was 27.90%.
Severity of thrombocytopenia had a significant association with retinal abnormalities. Occurrence of fundus changes increases with an increase in severity of thrombocytopenia. Fundus changes were found in all patients with grade IV thrombocytopenia.
研究登革热患者的视网膜变化，并检查这些变化是否可作为疾病严重程度和进展的充分指标。
患者/方法：记录了118例患者的详细病史，并对其进行了眼科检查，包括直接检眼镜检查、间接检眼镜检查和彩色眼底照相。
47%的患者被发现有眼后段异常。视网膜静脉扩张或迂曲是最常见的发现，其次是视盘改变（8.4%的患者）和视网膜出血（6.7%的患者）。随着血小板减少症严重程度的增加，视网膜异常患者的比例也增加。在I级血小板减少症患者中，未发现眼底异常。在II级血小板减少症患者中，13.63%的患者有眼底异常，而在III级患者中，这一比例为27.90%。
血小板减少症的严重程度与视网膜异常有显著关联。眼底改变的发生率随着血小板减少症严重程度的增加而增加。在所有IV级血小板减少症患者中均发现了眼底改变。
