Haus O, Podolak-Dawidziak M, Sasiadek M, Plewa R, Chichłowska-Sliwińska M
Department of Pathophysiology, Medical Academy, Wrocław, Poland.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1989;116(1):161-5.
We observed multiple uncommon chromosome abnormalities resulting in marker formation in a patient with AMMoL-M4. The breakpoints of the aberrations corresponded to common "cancer breakpoints" described by Mitelman and also--to localisation of some protooncogenes. The activation of these multiple protooncogenes in the described case might result in rapid progression of the disease and in the resistance to therapy.
我们在一名急性粒单核细胞白血病M4型（AMMoL-M4）患者中观察到多个罕见的染色体异常，这些异常导致了标记染色体的形成。这些畸变的断点与米特尔曼描述的常见“癌症断点”相对应，并且还与一些原癌基因的定位相对应。在所描述的病例中，这些多个原癌基因的激活可能导致疾病的快速进展和对治疗的耐药性。
