Whang-Peng J, Lee E C, Kao-Shan C S, Schechter G
Cytogenetic Oncology Section, NCI, Bethesda, Maryland 20892.
Hematol Pathol. 1987;1(1):57-65.
The presence of ring chromosomes is a rare finding in patients with de novo acute nonlymphocytic leukemia (ANLL). In this report we describe the cytogenetic abnormalities, including ring chromosomes, of a 45-year-old white male who had ANLL of the myelomonocytic type (M4). All of the leukemic cells had both a small unidentified ring and a medium-sized ring which was derived from chromosomes 2 and 11, r(2;11)(2p25;11p15q23;2q37). Four different types of rings or other structural abnormalities were derived from this medium-sized ring. A review of the literature indicated that the median survival of ANLL patients with either identified or unidentified ring chromosomes was 5 to 6 months, and that the presence of these cytogenetic abnormalities was related to a poor prognosis.
环状染色体在初发急性非淋巴细胞白血病（ANLL）患者中是一种罕见的发现。在本报告中，我们描述了一名45岁白人男性髓单核细胞型（M4）ANLL患者的细胞遗传学异常，包括环状染色体。所有白血病细胞均有一个小的未识别环状染色体和一个中等大小的环状染色体，后者由2号和11号染色体衍生而来，即r(2;11)(2p25;11p15q23;2q37)。从这个中等大小的环状染色体衍生出四种不同类型的环状染色体或其他结构异常。文献回顾表明，具有已识别或未识别环状染色体的ANLL患者的中位生存期为5至6个月，并且这些细胞遗传学异常的存在与预后不良相关。
