兰尼碱受体2磷酸化在心力衰竭和心律失常中的作用：心脏病中围绕兰尼碱受体磷酸化的争议
Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.
作者信息
Dobrev Dobromir, Wehrens Xander H T
机构信息
From the Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (D.D.); and Cardiovascular Research Institute, Departments of Molecular Physiology and Biophysics, and Medicine-Cardiology, Baylor College of Medicine, Houston, TX (X.H.T.W.).
出版信息
Circ Res. 2014 Apr 11;114(8):1311-9; discussion 1319. doi: 10.1161/CIRCRESAHA.114.300568.
Abstract
Cardiac ryanodine receptor type 2 plays a key role in excitation-contraction coupling. The ryanodine receptor type 2 channel protein is modulated by various post-translational modifications, including phosphorylation by protein kinase A and Ca(2+)/calmodulin protein kinase II. Despite extensive research in this area, the functional effects of ryanodine receptor type 2 phosphorylation remain disputed. In particular, the potential involvement of increased ryanodine receptor type 2 phosphorylation in the pathogenesis of heart failure and arrhythmias remains a controversial area, which is discussed in this review article.
摘要
心肌兰尼碱受体2型在兴奋-收缩偶联中起关键作用。兰尼碱受体2型通道蛋白受多种翻译后修饰的调节，包括蛋白激酶A和Ca(2+)/钙调蛋白依赖性蛋白激酶II的磷酸化。尽管该领域已有广泛研究，但兰尼碱受体2型磷酸化的功能效应仍存在争议。特别是，兰尼碱受体2型磷酸化增加在心力衰竭和心律失常发病机制中的潜在作用仍是一个有争议的领域，本文对此进行了讨论。
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