Ohshima Koichi
Nihon Rinsho. 2014 Mar;72(3):445-9.
Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare and heterogeneous forms of non-Hodgkin lymphoma (NHL) that, in general, are associated with a poor clinical outcome. In addition, many subtypes are present in the World Health Organization (WHO) classification of PTCL. To well classify and diagnose the PTCL, clinical, molecular, morphological and phenotypic data are necessary. For example, human T-cell leukemia virus type 1 (HTLV-I) provirus is necessary for the diagnosis of adult T-cell leukemia/lymphoma (ATLL). The t(2 : 5) and ALK expression are necessary for anaplastic lymphoma kinase (ALK) positive anaplastic large cell lymphoma (ALK+ ALCL). Epstein-Barr virus (EBV) is necessary for NKTCL.
外周T细胞淋巴瘤（PTCL）和自然杀伤/T细胞淋巴瘤（NKTCL）是非霍奇金淋巴瘤（NHL）中罕见且异质性的类型，总体而言，其临床预后较差。此外，世界卫生组织（WHO）对PTCL的分类中有许多亚型。为了准确分类和诊断PTCL，临床、分子、形态学和表型数据是必要的。例如，成人T细胞白血病/淋巴瘤（ATLL）的诊断需要检测1型人类T细胞白血病病毒（HTLV-I）前病毒。间变性淋巴瘤激酶（ALK）阳性间变性大细胞淋巴瘤（ALK+ ALCL）的诊断需要检测t(2 : 5)和ALK表达。NKTCL的诊断需要检测爱泼斯坦-巴尔病毒（EBV）。
