高分辨率熔解分析用于 IFNL4 相关二核苷酸变异 rs368234815 的基因分型。
High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815.
机构信息
Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
出版信息
Clin Microbiol Infect. 2014 Nov;20(11):O936-8. doi: 10.1111/1469-0691.12637. Epub 2014 May 15.
Interferon-λ4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high-resolution melting genotyping assay using 193 patients with chronic hepatitis C.
干扰素-λ4 相关二核苷酸变异 rs368234815 TT/-G 与 rs12979860 多态性密切相关，后者是与治疗诱导的丙型肝炎病毒清除相关的最重要遗传标志物。由于 rs368234815 多态性可能为慢性丙型肝炎的管理提供额外的基线信息，因此我们开发并验证了一种使用 193 例慢性丙型肝炎患者的高分辨率熔解基因分型检测方法。
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