Department of Chemistry, Indian Institute of Technology Madras , Chennai - 600036, India.
Org Lett. 2014 May 2;16(9):2510-3. doi: 10.1021/ol500874p. Epub 2014 Apr 11.
An efficient rhodium catalyzed direct arylation of α-diazoimines, generated from readily accessible 1,2,3-triazole, has been accomplished for the synthesis of 2,2-diaryl enamides. The reaction involves the chemo- and regioselective insertion of rhodium azavinyl carbene into aromatic C(sp(2))-H bonds. Utility of the developed methodology was demonstrated in the synthesis of indole and tetrahydroisoquinoline frameworks.
一种高效的铑催化的α-重氮亚胺的直接芳基化反应已经被实现，该反应由易得的 1,2,3-三唑生成，用于合成 2,2-二芳基烯酰胺。该反应涉及铑氮烯卡宾的化学选择性和区域选择性插入芳基 C(sp(2))-H 键。所开发的方法学的实用性在吲哚和四氢异喹啉骨架的合成中得到了证明。
