Kondziolka D, Bilbao J M
Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Ontario, Canada.
J Neurosurg. 1989 Jul;71(1):91-7. doi: 10.3171/jns.1989.71.1.0091.
Monoclonal and polyclonal antisera were used against 12 cases of neuroepithelial (colloid) cysts to determine the specific antigenic profile of the cyst epithelium. Intermediate filament markers (cytokeratin, vimentin, neurofilament, and glial fibrillary acidic protein) and epithelial markers (epithelial membrane antigen and monoclonal antibody lu-5) demonstrated that colloid cyst epithelium has a unique antigenic profile in contrast to that of choroid plexus or glial tissue. Theories raised to explain the etiology of colloid cysts have included derivation from the embryonic paraphysis, detachments of developing neuroepithelium from the tela choroidea, and remnants of respiratory epithelium; a more recent theory suggests that these cysts are products of developing choroid plexus or ependyma. The present study shows that colloid cyst epithelium is distinct from that of choroid plexus or ependyma and therefore does not represent a product of their formation, nor does it represent a form of immature glia. This finding supports the conclusion that colloid cysts in any ventricular location represent a developmental anomaly of primitive neuroectoderm in the embryo, which remains unique from other products of neuroectodermal derivation.
使用单克隆和多克隆抗血清对12例神经上皮（胶体）囊肿进行检测，以确定囊肿上皮的特异性抗原谱。中间丝标志物（细胞角蛋白、波形蛋白、神经丝和胶质纤维酸性蛋白）和上皮标志物（上皮膜抗原和单克隆抗体lu-5）表明，与脉络丛或神经胶质组织相比，胶体囊肿上皮具有独特的抗原谱。为解释胶体囊肿的病因提出的理论包括源自胚胎旁突体、发育中的神经上皮从脉络膜组织分离以及呼吸上皮的残余物；最近的一种理论认为，这些囊肿是发育中的脉络丛或室管膜的产物。本研究表明，胶体囊肿上皮与脉络丛或室管膜的上皮不同，因此既不代表它们形成的产物，也不代表未成熟神经胶质的一种形式。这一发现支持了这样的结论，即任何脑室部位的胶体囊肿代表胚胎中原始神经外胚层的发育异常，它与神经外胚层衍生的其他产物仍然不同。
