钯催化酰腙与异氰的氧化环化反应：2-氨基-1,3,4-噁二唑的合成。
Pd-catalyzed oxidative annulation of hydrazides with isocyanides: synthesis of 2-amino-1,3,4-oxadiazoles.
机构信息
Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
出版信息
Org Lett. 2014 May 2;16(9):2342-5. doi: 10.1021/ol5006449. Epub 2014 Apr 11.
PMID:24725151
Abstract
An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4-oxadiazoles and their derivatives.
摘要
发展了一种高效的钯催化氧化环化反应，通过顺序将异氰化物插入酰肼的 N-H 和 O-H 键中，为有价值的 2-氨基-1,3,4-噁二唑及其衍生物提供了有效的合成途径。
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