前列腺癌遗传变异的流行病学和临床意义。
The epidemiology and clinical implications of genetic variation in prostate cancer.
机构信息
Department of Surgery, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 2650 Ridge Avenue, Evanston, IL 60201, USA.
Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Superior Avenue, Terry Building 16, Chicago, IL 60611, USA.
出版信息
Urol Clin North Am. 2014 May;41(2):277-97. doi: 10.1016/j.ucl.2014.01.001. Epub 2014 Feb 28.
There is strong evidence of a genetic predisposition to prostate cancer. Recent advances in genetic sequencing technologies have permitted significant advances in the field. This article reviews the genetic basis underlying prostate cancer, and highlights the epidemiology and potential clinical usefulness of both rare and common genetic variations. In addition, recent findings related to the understanding of prostate cancer genetics are discussed.
强烈证据表明前列腺癌存在遗传易感性。遗传测序技术的最新进展使得该领域取得了重大进展。本文回顾了前列腺癌的遗传基础，并重点介绍了罕见和常见遗传变异的流行病学和潜在临床应用。此外，还讨论了与理解前列腺癌遗传学相关的最新发现。
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