State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Parasit Vectors. 2014 Apr 13;7:180. doi: 10.1186/1756-3305-7-180.
Toxoplasma gondii is an obligate intracellular parasitic protozoan that has a wide host range and causes a zoonotic parasitosis called toxoplasmosis. This infection causes significant morbidity, costs for care and loss of productivity and suffering. The most effective measures to minimize this parasite's harm to patients are prompt diagnosis and treatment and preventing infection. A parasite surface antigen, SAG1, is considered an important antigen for the development of effective diagnostic tests or subunit vaccines. This review covers several aspects of this antigen, including its gene structure, contribution to host invasion, mechanisms of the immune responses and its applications for diagnosis and vaccine development. This significant progress on this antigen provides foundations for further development of more effective and precise approaches to diagnose toxoplasmosis in the clinic, and also have important implications for exploring novel measures to control toxoplasmosis in the near future.
刚地弓形虫是一种专性细胞内寄生的原生动物，宿主范围广泛，可引起一种称为弓形虫病的人畜共患寄生虫病。这种感染会导致严重的发病率、医疗费用以及生产力和生活质量的损失。最大限度地减少这种寄生虫对患者的危害的最有效措施是及时诊断和治疗以及预防感染。寄生虫表面抗原 SAG1 被认为是开发有效诊断检测或亚单位疫苗的重要抗原。本综述涵盖了该抗原的几个方面，包括其基因结构、对宿主入侵的贡献、免疫反应机制及其在诊断和疫苗开发中的应用。该抗原的这一重要进展为进一步开发更有效和精确的方法来诊断临床中的弓形虫病提供了基础，也为探索未来控制弓形虫病的新措施提供了重要依据。
