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小儿及青少年尿道狭窄行尿道成形术后复发的预测因素

Predictors for recurrence after urethroplasty in pediatric and adolescent stricture urethra.

作者信息

Vashishtha Saurabh, Sureka Sanjoy Kumar, Kumar Jatinder, Prabhakaran Sandeep, Kapoor Rakesk, Ansari M S

机构信息

Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, U.P., India.

Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, U.P., India.

出版信息

J Pediatr Urol. 2014 Apr;10(2):268-73. doi: 10.1016/j.jpurol.2013.08.014. Epub 2013 Sep 25.

DOI:10.1016/j.jpurol.2013.08.014
PMID:24726239
Abstract

OBJECTIVE

This study aims at evaluating factors predicting recurrence of urethral stricture following urethroplasty in pediatric patients at a tertiary care center.

PATIENTS AND METHODS

Fifty-two patients of up to 18 years of age, who underwent urethroplasty, were reviewed. Duration of symptoms, etiology, previous intervention, and site of stricture, surgical modality, stricture length, and spongiofibrosis at stricture site, recurrence, and ancillary procedures required were recorded.

RESULTS

Forty-two (82.76%) patients (Group I) had recurrence-free course on follow-up. Of the 10 patients with recurrence (Group II), 9 had PTS and 1 had IS (p = 0.04). Most of the factors evaluated did not differ statistically between the groups; however, length of stricture (1.8 vs. 4.3 cm, p < 0.001) and degree of spongiofibrosis (61% vs. 90%, p = 0.003) were significantly different. Seven patients with recurrence were managed with single procedures, but three required multiple procedures because of multiple recurrences. History of incision and drainage for paraurethral abscess was significantly higher (28.6% vs. 100%, p = 0.002) in patients who had multiple recurrences.

CONCLUSIONS

Etiology, fibrosis at local site, and stricture length have significant impact on recurrence of pediatric urethral stricture disease. Associated paraurethral abscess may further compromise the outcome of urethroplasty.

摘要

目的

本研究旨在评估在一家三级医疗中心接受尿道成形术的儿科患者尿道狭窄复发的预测因素。

患者与方法

对52例年龄在18岁及以下接受尿道成形术的患者进行了回顾性研究。记录症状持续时间、病因、既往干预措施、狭窄部位、手术方式、狭窄长度、狭窄部位的海绵体纤维化情况、复发情况以及所需的辅助手术。

结果

42例(82.76%)患者(第一组)在随访期间无复发。在10例复发患者(第二组)中,9例患有创伤性尿道狭窄(PTS),1例患有特发性狭窄(IS)(p = 0.04)。评估的大多数因素在两组之间无统计学差异;然而,狭窄长度(1.8对4.3 cm,p < 0.001)和海绵体纤维化程度(61%对90%,p = 0.003)有显著差异。7例复发患者通过单次手术处理,但3例因多次复发需要多次手术。多次复发患者既往尿道旁脓肿切开引流史显著更高(28.6%对100%,p = 0.002)。

结论

病因、局部纤维化和狭窄长度对小儿尿道狭窄疾病的复发有显著影响。相关的尿道旁脓肿可能会进一步影响尿道成形术的效果。

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