B 淋巴细胞与骨骼系统之间的紧密关系。

Tight relationships between B lymphocytes and the skeletal system.

机构信息

Molecular and Cell Biology Unit, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA; Quantitative and Systems Biology Graduate Group, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Inserm UMR-S 606 1132, Paris, F-75475, France; Université Paris Diderot, Sorbone Paris Cité, Paris, F-75475, France.

出版信息

Trends Mol Med. 2014 Jul;20(7):405-12. doi: 10.1016/j.molmed.2014.03.003. Epub 2014 Apr 10.

DOI:10.1016/j.molmed.2014.03.003

PMID:24726716

Abstract

Mounting evidence indicates that the immune system and the skeletal system share several regulatory nodes. B lymphocytes, which play key roles in immune homeostasis, are uniquely endowed with osteointeractive properties. From their early development to the plasma cell stage, they are in close proximity with the skeletal system and produce factors important for bone maintenance. Not surprisingly, perturbation of B lymphopoiesis affects bone mass. Reciprocally, inactivation of bone cell functions results in B cell development blocks. This new understanding is refining our insights into the pathogenesis of several diseases such as periodontitis and rheumatoid arthritis.

摘要

越来越多的证据表明，免疫系统和骨骼系统共享几个调节节点。B 淋巴细胞在免疫稳态中发挥关键作用，它们具有独特的骨相互作用特性。从早期发育到浆细胞阶段，B 淋巴细胞与骨骼系统密切相关，并产生维持骨骼健康的重要因子。毫不奇怪，B 淋巴细胞生成受到干扰会影响骨量。相反，骨细胞功能的失活会导致 B 细胞发育受阻。这种新的认识正在深化我们对几种疾病（如牙周炎和类风湿性关节炎）发病机制的理解。