State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China.
Int Immunopharmacol. 2024 May 30;133:112151. doi: 10.1016/j.intimp.2024.112151. Epub 2024 Apr 28.
Osteoclasts are pivotal in regulating bone metabolism, with immune cells significantly influencing both physiological and pathological processes by modulating osteoclast functions. This is particularly evident in conditions of inflammatory bone resorption, such as rheumatoid arthritis and periodontitis. This review summarizes and comprehensively analyzes the research progress on the regulation of osteoclast formation by immune cells, aiming to unveil the underlying mechanisms and pathways through which diseases, such as rheumatoid arthritis and periodontitis, impact bone metabolism.
破骨细胞在调节骨代谢中起着关键作用，免疫细胞通过调节破骨细胞的功能显著影响生理和病理过程。在炎症性骨吸收的情况下，如类风湿关节炎和牙周炎，这种影响尤为明显。本文总结和综合分析了免疫细胞对破骨细胞形成的调控作用的研究进展，旨在揭示类风湿关节炎和牙周炎等疾病影响骨代谢的潜在机制和途径。
