Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
FEBS Lett. 2014 Aug 19;588(16):2610-5. doi: 10.1016/j.febslet.2014.03.054. Epub 2014 Apr 12.
MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.
MicroRNAs 是基因表达的有效调节因子，调节包括增殖、分化和凋亡在内的多种细胞过程。已经证明，许多 microRNAs 受 p53 调节，p53 是人类癌症中最常突变的基因。已经表明，一些突变型 p53 蛋白不仅丧失了肿瘤抑制活性，而且还获得了与野生型 p53 无关的新的致癌功能。在这篇综述中，我们强调了最近的证据表明，一些突变型 p53 蛋白通过调节特定 microRNAs 的表达来获得致癌功能，并确定了受突变型 p53 下游 microRNAs 调节的基因网络。
