HLA-Dw‘RSH’：一种与HLA-DRw18(3)相关的新的HLA-Dw特异性

HLA-Dw 'RSH': a new HLA-Dw specificity associated with HLA-DRw18(3).

作者信息

Oudshoorn M, du Toit E D, Taljaard D G

机构信息

Provincial Laboratory for Tissue Immunology, Cape Town, South Africa.

出版信息

Tissue Antigens. 1989 Mar;33(3):367-74. doi: 10.1111/j.1399-0039.1989.tb01679.x.

DOI:10.1111/j.1399-0039.1989.tb01679.x

PMID:2472677

Abstract

The present study describes a new HLA-Dw specificity, Dw'RSH'. HLA-Dw'RSH' is associated with DRw18(3) and is clearly different to the DRw17(3) associated specificity Dw3. Dw'RSH' was shown to be the most common Dw specificity found in the South African (SA) Negroes (gf = 0.10) and was less common in Cape Coloureds (gf = 0.01). The specificity was absent in the SA Caucasoids tested. Dw'RSH' is part of the common Negro haplotype Bw42, DRw18, DQw4 which is seen as commonly in the SA Negroes as the B8, DRw17, DQw2, Dw3 haplotype is seen in the Caucasoids.

摘要

本研究描述了一种新的HLA-Dw特异性，即Dw'RSH'。HLA-Dw'RSH'与DRw18(3)相关，且明显不同于与DRw17(3)相关的特异性Dw3。已证明Dw'RSH'是在南非黑人中发现的最常见的Dw特异性（基因频率=0.10），而在开普混血人种中则不太常见（基因频率=0.01）。在所检测的南非白种人中不存在这种特异性。Dw'RSH'是常见黑人单倍型Bw42、DRw18、DQw4的一部分，在南非黑人中出现的频率与白种人中B8、DRw17、DQw2、Dw3单倍型出现的频率一样常见。